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United States

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製品番号: HY-P10841

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CyPep-1

CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1319804-91-5
分子式: C₁₅₂H₂₆₅N₅₇O₃₅
分子量:3451.09

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CyPep-1 構造式

CAS 番号: 1319804-91-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CyPep-1 (0-40 μg/mL; 15-360 min) produces toxicity to tumor cell lines in a dose- and time-dependent manner, with little effect on normal cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

CyPep-1 (intratumoral injection; 1200 µg; single dose) has antitumor effect in mouse model of breast cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4T1 murine metastatic breast cancer cells treated female BALB/c mice (average age 12625 days; average weight 23.8g)^[1]
Dosage:

1200 µg
Administration:

Intratumoural injection; single dose
Result:

Did not cause any signs of discomfort, pain or toxicity.
Significantly reduced tumour growth and caused massive necrosis of the tumours.
Prolonged the median survival time of mice.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 1319804-91-5
分子量 3451.09
分子式 C₁₅₂H₂₆₅N₅₇O₃₅
配列

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Lys-Thr-Leu-Arg-Val-Ala-Lys-Ala-Ile-Tyr-Lys-Arg-Tyr-Ile-Glu
シーケンスの短縮

YGRKKRRQRRRGKTLRVAKAIYKRYIE
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (261 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Szczepanski C, et al. Identification of a novel lytic peptide for the treatment of solid tumours. Genes Cancer. 2014 May;5(5-6):186-200. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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