Diquafosol
Based on 5 publication(s) in Google Scholar
Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 59985-21-6
- 分子式: C18H26N4O23P4
- 分子量:790.31
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Diquafosol
MoreP2Y Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
P2Y2 Receptor |
Diquafosol (3%; 24 h) inhibits apoptosis and decreases ROS generation in dry-conditioned hCECs[1].
Diquafosol (3%; 24 h) increases the protein expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK in hCECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:human corneal epithelial cells (hCECs)
-
Concentration:3% (diluted at 1:100)
-
Incubation Time:24 h
-
Result:Increased the protein expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:6 weeks, 160-180 g Wistar female rats (dry eye model)[1]
-
Dosage:ophthalmic solution 3%
-
Administration:eyedrop, four times daily (8, 12 AM; 4, 8 PM) for 28 days
-
Result:Increased the expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK, inhibits apoptosis, decreased the IL-1β, TNF-α expression.
化学情報
-
CAS 番号 59985-21-6
-
分子量 790.31
-
分子式 C18H26N4O23P4
-
SMILES
O[C@H]1[C@@H](O)[C@H](N(C(N2)=O)C=CC2=O)O[C@@H]1COP(O)(OP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(NC(C=C4)=O)=O)O3)(O)=O)(O)=O)(O)=O)=O
-
別名
INS365 free base
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Cell Prolif
Establishment of human corneal epithelial organoids for ex vivo modelling dry eye disease. [Abstract]2024 Nov;57(11):e13704. PMID: 38961590 -
Commun Biol
2023 Aug 29;6(1):889. PMID: 37644178 -
Int J Mol Sci
2022 Jul 17;23(14):7870. PMID: 35887219 -
-
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Diquafosol 関連分類
HY-B0606A 関連分類
Powered by Bioz