FGI-106
Based on 1 publication(s) in Google Scholar
FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 501081-38-5
- 分子式: C28H38N6
- 分子量:458.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 FGI-106
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生物活性
製品説明
IC50 & Target
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HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
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Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
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[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
|
[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
|
[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
|
[PMID: 26771861] |
体外実験
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM[1].
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)[1]
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Dosage:0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
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Administration:Intraperitoneal injection; treatments on days 2 and 5
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Result:Decreased mortality from Zaire EBOV in a dose-dependent manner.
化学情報
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CAS 番号 501081-38-5
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分子量 458.64
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分子式 C28H38N6
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SMILES
CC1=CC(NCCCN(C)C)=C2C=CC3=C4N=C(C)C=C(NCCCN(C)C)C4=CC=C3C2=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FGI-106 関連分類
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