FGI-106
Based on 1 publication(s) in Google Scholar
FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 501081-38-5
- 分子式: C28H38N6
- 分子量:458.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 FGI-106
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生物活性
製品説明
IC50 & Target
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HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
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Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
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[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
|
[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
|
[PMID: 26771861] |
| Vero C1008 | EC50 |
0.4 μM
Compound: 87
|
Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry
|
[PMID: 26771861] |
体外実験
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM[1].
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)[1]
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Dosage:0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
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Administration:Intraperitoneal injection; treatments on days 2 and 5
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Result:Decreased mortality from Zaire EBOV in a dose-dependent manner.
化学情報
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CAS 番号 501081-38-5
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分子量 458.64
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分子式 C28H38N6
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SMILES
CC1=CC(NCCCN(C)C)=C2C=CC3=C4N=C(C)C=C(NCCCN(C)C)C4=CC=C3C2=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FGI-106 関連分類
HY-124618 関連分類
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