FLT3-IN-16
Based on 1 Customer Validation
FLT3-IN-16 is a potent FLT3 inhibitor with an IC50 of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.98%
- CAS 番号: 298207-49-5
- 分子式: C15H15N3O2S
- 分子量:301.36
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
IC50: 1.1 μM (FLT3)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HEK-293T | CC50 |
>250 μM
Compound: 8
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Cytotoxicity against human HEK293T cells after 24 hrs by MTT assay
Cytotoxicity against human HEK293T cells after 24 hrs by MTT assay
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[PMID: 24785979] |
| MDCK | CC50 |
45.2 μM
Compound: 8
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Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
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[PMID: 24785979] |
| MV4-11 | IC50 |
2 μM
Compound: 9
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Antiproliferative activity against human MV4-11 cells
Antiproliferative activity against human MV4-11 cells
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[PMID: 16580199] |
体外実験
FLT3-IN-16 (compound 9, 0-10 μM) exhibits anti-proliferative activities against MV4-11 cells with an IC50 value of 2.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 298207-49-5
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性状 Solid
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分子量 301.36
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分子式 C15H15N3O2S
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Color Off-white to light yellow
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SMILES
O=C(C1=C(NC(C2=CC=CN=C2)=O)SC3=C1CCCC3)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 25 mg/mL (82.96 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3183 mL | 16.5915 mL | 33.1829 mL | 82.9573 mL |
| 5 mM | 0.6637 mL | 3.3183 mL | 6.6366 mL | 16.5915 mL | |
| 10 mM | 0.3318 mL | 1.6591 mL | 3.3183 mL | 8.2957 mL | |
| 15 mM | 0.2212 mL | 1.1061 mL | 2.2122 mL | 5.5305 mL | |
| 20 mM | 0.1659 mL | 0.8296 mL | 1.6591 mL | 4.1479 mL | |
| 25 mM | 0.1327 mL | 0.6637 mL | 1.3273 mL | 3.3183 mL | |
| 30 mM | 0.1106 mL | 0.5530 mL | 1.1061 mL | 2.7652 mL | |
| 40 mM | 0.0830 mL | 0.4148 mL | 0.8296 mL | 2.0739 mL | |
| 50 mM | 0.0664 mL | 0.3318 mL | 0.6637 mL | 1.6591 mL | |
| 60 mM | 0.0553 mL | 0.2765 mL | 0.5530 mL | 1.3826 mL | |
| 80 mM | 0.0415 mL | 0.2074 mL | 0.4148 mL | 1.0370 mL |
FLT3-IN-16 関連分類
HY-148036 関連分類
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