LYPLA2 - lysophospholipase 2 Gene

Also Known as APT2; APT-2; DJ886K2.4

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 11313

About LYPLA2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,791,145-23,795,539 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues.

Summary

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

LYPLA2 Products (1)

mRNA	Protein	Name
NM_007260.3	NP_009191.1	acyl-protein thioesterase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	25301951	GOA
enables palmitoyl-(protein) hydrolase activity	IDA IDA: Inferred from direct assay	28826475	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in acylglycerol catabolic process	IDA IDA: Inferred from direct assay	25301951	GOA
involved in prostaglandin catabolic process	IDA IDA: Inferred from direct assay	25301951	GOA
involved in protein depalmitoylation	IDA IDA: Inferred from direct assay	28826475	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYPLA2 Protein Structure

Abhydrolase_2

0
100
200
231 a.a.

Protein Preferred Names	Protein Names
acyl-protein thioesterase 2	LPL-II

LYPLA2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	LYPLA2	O95372	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	LYPLA2	O95372	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	LYPLA2	O95372	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYPLA2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70221	Acyl-protein thioesterase 2/LYPLA2 Protein, Human (His)	O95372 (M1-V231)	≥ 95%, as determined by reducing SDS-PAGE.

Diseases	Alias
Hypotonia-Cystinuria Syndrome	Cystinuria With Mitochondrial Disease 2p21 Microdeletion Syndrome HCS Homozygous 2p16 Deletion Syndrome, Formerly 2p21 Deletion Syndrome Del(2)(P21) Monosomy 2p21 Atypical Hypotonia-Cystinuria Syndrome Atypical Hcs
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-100736	ML348	Inhibitor	99.97%	Unkown
HY-100737	ML349	Inhibitor	99.47%	Unkown
HY-128035	ML-211	Inhibitor	99.85%	Unkown
HY-129121	ML-226	Inhibitor	98.76%	Unkown
HY-120126	ML378	Inhibitor	/	Unkown
HY-RS07922	LYPLA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18712	Lypla2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25199	Lypla2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	LYPLA2	MGD	MGI:1347000
Macaca mulatta	LYPLA2	VGNC	VGNC:74465
Canis familiaris	LYPLA2	VGNC	VGNC:42891
Felis catus	LYPLA2	VGNC	VGNC:68112
Bos taurus	LYPLA2	VGNC	VGNC:31106
Rattus norvegicus	LYPLA2	RGD	RGD:620210
Others	LYPLA2	NCBI