Cd3e - CD3 antigen, epsilon polypeptide Gene

Also Known as CD3; T3e; CD3epsilon

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 12501

Summary

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3e (CD3e molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd3e Products (1)

mRNA Protein Name
NM_007648.5 NP_031674.1 T-cell surface glycoprotein CD3 epsilon chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
8196616 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of T cell activation IDA
IDA: Inferred from direct assay
12874832 MGI
acts upstream of T cell anergy IDA
IDA: Inferred from direct assay
14973438 MGI
acts upstream of or within T cell costimulation IGI
IGI: Inferred from genetic interaction
23793062 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
10072077 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
10485657 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
8666928 MGI
acts upstream of calcium-mediated signaling IDA
IDA: Inferred from direct assay
7630421 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
7630421 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
17502348 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
17502348 MGI
acts upstream of interleukin-4 production IDA
IDA: Inferred from direct assay
11894097 MGI
acts upstream of or within lymphocyte activation IMP
IMP: Inferred from mutant phenotype
15843560 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
10981962 MGI
acts upstream of or within negative thymic T cell selection IDA
IDA: Inferred from direct assay
7630421 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10485657 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of or within positive regulation of T cell activation IDA
IDA: Inferred from direct assay
12874832 MGI
acts upstream of or within positive regulation of T cell anergy IDA
IDA: Inferred from direct assay
14973438 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
10072077 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
7630421 MGI
involved in positive regulation of cell-cell adhesion mediated by integrin IGI
IGI: Inferred from genetic interaction
12652296 MGI
involved in positive regulation of cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
12652296 MGI
acts upstream of or within positive regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
12874832 MGI
acts upstream of or within positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
11894097 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10485657 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11894097 MGI
acts upstream of smoothened signaling pathway IDA
IDA: Inferred from direct assay
10981962 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
11894097 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
part of alpha-beta T cell receptor complex IDA
IDA: Inferred from direct assay
9064344 MGI
located in cell body IDA
IDA: Inferred from direct assay
17502348 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
17502348 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7630421 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
14635057 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17502348 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD3 epsilon chain

  • T-cell surface antigen T3/Leu-4 epsilon chain

Recombinant Cd3e Proteins

製品番号 製品名 アクセッション番号 純度
HY-P75414 CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc) NP_031674.1 (D23-D108)&NP_033980.1 (Q23-S116) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75415 CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Flag-His) P04235 (F22-A105)&P22646 (D22-D108) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P75416 CD3D-CD3E Heterodimer Protein, Mouse (HEK293) P04235 (F22-A105)&P22646 (D22-D108) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77614 CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Fc) P04235 (F22-A105)&P22646 (D23-D108) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

阻害性抗体 (2)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-P9963 Blinatumomab Inhibitor 98.78% Unkown
HY-P99909 Elranatamab 98.74% Unkown

Clinical Phase

阻害性抗体 (13)
製品番号 製品名 製品効果
純度 Phase
HY-P990932 Obrixtamig Inhibitor 99.9% Phase 3
HY-P99332 Visilizumab Inducer 98.48% Phase 3
HY-P990920 Gocatamig Inhibitor ≥99.0% Phase 2
HY-P990953 Zubotamig Inhibitor 96.46% Phase 2
HY-P99914 Emfizatamab Activator 95.495% Phase 2
HY-P991708 Olsutamig Inhibitor 99.00% Phase 2
HY-P99896 Runimotamab 99.00% Phase 1
HY-P99868 Duvortuxizumab ≥99.0% Phase 1
HY-P99798 Pacanalotamab Chemical 97.04% Phase 1
HY-P991681 Emaretamig Inhibitor 97.96% Phase 1
HY-P990692 Ciduvectamig Inhibitor 95.879% Phase 1
HY-P991469 AMG-211 Inhibitor / Phase 1
HY-P991671 Anafiltamig Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02243 CD3E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17021 Cd3e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23464 Cd3e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (16)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990903 Avitotamig Inhibitor 95.98% Unkown
HY-P991706 Nelvutamig Inhibitor 97.76% Unkown
HY-P991034 Trevotamig Inhibitor 95.539% Unkown
HY-P991686 Gamgertamig Inhibitor 99.32% Unkown
HY-P990714 Obertamig Inhibitor 95.803% Unkown
HY-P991461 AMG-424 Inhibitor 99.32% Unkown
HY-P990939 Podentamig Inhibitor / Unkown
HY-P992136 Torutamig Inhibitor / Unkown
HY-P992145 Zeclantamig 95.38% Unkown
HY-P990698 Umizortamig 96.90% Unkown
HY-P991700 Lumivatamig Inhibitor 97.24% Unkown
HY-P992140 Varzutamig Inhibitor / Unkown
HY-P991463 MS133 Inhibitor / Unkown
HY-P991552 AFM15 Inducer / Unkown
HY-P992061 Anti-Mouse CD3E Antibody (500A2) / Unkown
HY-P992370 HPN601 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Cd3e NCBI NCBI:916