Chat - choline acetyltransferase Gene

Also Known as CHOACTase; B230380D24Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 12647

Summary

Enables choline O-acetyltransferase activity. Acts upstream of or within several processes, including adult walking behavior; establishment of synaptic specificity at neuromuscular junction; and rhythmic excitation. Located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including alimentary system; cranium; heart; nervous system; and retina. Used to study congenital myasthenic syndrome 6. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Chat Products (1)

mRNA Protein Name
NM_009891.2 NP_034021.1 choline O-acetyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables choline O-acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
12441053 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
15820692 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12533614 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
12441053 MGI
acts upstream of or within establishment of synaptic specificity at neuromuscular junction IMP
IMP: Inferred from mutant phenotype
12533614 MGI
acts upstream of or within muscle organ development IMP
IMP: Inferred from mutant phenotype
12441053 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
12441053 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
12441053 MGI
acts upstream of or within rhythmic behavior IMP
IMP: Inferred from mutant phenotype
15820692 MGI
acts upstream of or within rhythmic excitation IMP
IMP: Inferred from mutant phenotype
15820692 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in axon IDA
IDA: Inferred from direct assay
19906978 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24462097 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
12115678 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
9853118 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

choline O-acetyltransferase

  • choline acetylase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-B0764 Bucladesine sodium Activator 99.36% Yes
HY-B0764R Bucladesine sodium (Standard) Activator 99.81% Unkown

Pre-clinical Phase

Bioactive Molecules (15)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-N7038 Phytohemagglutinin 80.00% Unkown
HY-N8376 Fustin 99.6% Unkown
HY-N0631 Cornuside Inhibitor 99.99% Unkown
HY-W100403 Choline tosylate Inhibitor 99.90% Unkown
HY-N4119 Neoeriocitrin 99.97% Unkown
HY-159904 ChAT IN-1 Inhibitor 98.51% Unkown
HY-N0801 Polygalacic acid Inhibitor 98.92% Unkown
HY-131574 Heliosupine N-oxide Inhibitor / Unkown
HY-183572 BW813U Inhibitor / Unkown
HY-N4119R Neoeriocitrin (Standard) Inhibitor / Unkown
HY-RS02597 CHAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12824 SH2D3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0631R Cornuside (Standard) Inhibitor / Unkown
HY-RS22115 Chat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28637 Chat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Chat NCBI NCBI:1103