OTOS - otospiralin Gene

Also Known as OTOSP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 150677

About OTOS

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,139,026-240,140,658 (from NCBI)

This gene has 2 transcripts (splice variants) and 185 orthologues. Restricted expression toward thyroid (RPKM 6.1).

Summary

Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]).[supplied by OMIM, Mar 2008]

OTOS Products (1)

mRNA Protein Name
NM_148961.4 NP_683764.1 otospiralin precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTOS Protein Structure

OTOS

OTOS: Otospiralin (21 - 89)

  • 0
  • 89 a.a.
Protein Preferred Names Protein Names

otospiralin

OTOS Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
OTOS Q8NHW6 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra
OTOS Q8NHW6 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra
OTOS Q8NHW6 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
OTOS Q8NHW6 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
OTOS Q8NHW6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
OTOS Q8NHW6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Deafness, X-Linked 2

  • Progressive Deafness With Stapes Fixation

  • DFNX2

  • Dfn3

  • Nance Deafness

  • Perilymphatic Gusher-Deafness Syndrome

  • Stapedo-Vestibular Ankylosis

  • Sensorineural Deafness, Profound, With Or Without A Conductive Component, Associated With A Unique Developmental Abnormality Of The Ear

  • X-Linked Deafness 2

  • X-Linked Mixed Conductive And Neurosensory Deafness

  • X-Linked Mixed Conductive And Sensorineural Deafness

  • Deafness 3 Conductive With Stapes Fixation

  • Deafness Conductive With Stapes Fixation

  • Deafness Mixed With Perilymphatic Gusher

  • Thies-Reis Syndrome

  • Deafness, Conductive, With Stapes Fixation

  • Deafness 3, Conductive, With Stapes Fixation

  • Deafness, Mixed, With Perilymphatic Gusher

  • Conductive Deafness 3 With Stapes Fixation

  • Conductive Deafness With Stapes Fixation

  • Mixed Deafness With Perilymphatic Gusher

  • X-Linked Deafness Type 2

  • X-Linked Mixed Conductive And Neurosensory Hearing Loss

  • X-Linked Mixed Conductive And Sensorineural Hearing Loss

  • X-Linked Sensorineural Deafness

  • X-Linked Stapes Gusher Syndrome

  • Deafness Mixed With Perilymphatic Gusher, X-Linked

  • Dfn 3 Nonsyndromic Hearing Loss And Deafness

  • Gusher Syndrome

  • Thies Reis Syndrome

  • Progressive Hearing Loss With Stapes Fixation

  • Deafness, X-Linked, 2

  • Deafness Mixed With Perilymph Gusher X-Linked

  • Deafness, X-Linked, Type 2

  • Progressive Hearing Loss Stapes Fixation
X-Linked Nonsyndromic Deafness

  • X-Linked Deafness

  • Deafness, X-Linked
Usher Syndrome, Type Ic

  • USH1C

  • Usher Syndrome Type 1c

  • Usher Syndrome, Type 1c

  • Usher Syndrome Type I Acadian Variety

  • Usher Syndrome Type Ic

  • Usher Syndrome, Type I, Acadian Variety

  • Usher Syndrome 1c

  • Acadian Usher Syndrome

  • Usher'S Syndrome Type 1c
Deafness, Autosomal Dominant 9

  • DFNA9

  • Autosomal Dominant Nonsyndromic Deafness 9

  • Autosomal Dominant Deafness 9

  • Deafness, Autosomal Dominant, 9

  • Deafness, Autosomal Dominant, Type 9
Autosomal Dominant Nonsyndromic Deafness

  • Autosomal Dominant Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09867 OTOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta OTOS VGNC VGNC:104547
Rattus norvegicus OTOS RGD RGD:708465
Bos taurus OTOS VGNC VGNC:55642
Felis catus OTOS VGNC VGNC:63998
Mus musculus OTOS MGD MGI:2672814
Canis familiaris OTOS VGNC VGNC:44181
Others OTOS NCBI