Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

Also Known as p65; p65 NFkB; p65 NF-kappa B

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 19697

About Rela

Chromosome 19: 5,687,511-5,698,158 forward strand.GRCm39:CM001012.3

This gene has 7 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 47 phenotypes. Ubiquitous expression in adrenal adult (RPKM 78.1), lung adult (RPKM 46.5) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; postsynapse to nucleus signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to lipopolysaccharide; and positive regulation of interleukin-12 production. Located in several cellular components, including chromatin; cytosol; and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela Products (3)

mRNA Protein Name
NM_001402548.1 NP_001389477.1 transcription factor p65 isoform p65 iso 3
NM_009045.5 NP_033071.1 transcription factor p65 isoform 1
NM_001365067.1 NP_001351996.1 transcription factor p65 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA binding IDA
IDA: Inferred from direct assay
10227969 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21329555 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14568984 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
29813070 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8289784 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
25152367 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15944286 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21402781 MGI
enables actinin binding IPI
IPI: Inferred from physical interaction
25411248 MGI
enables ankyrin repeat binding IPI
IPI: Inferred from physical interaction
21131967 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
19619491 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
22244329 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
19338389 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9556555 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21131967 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23184950 MGI
enables transcription regulator activity IDA
IDA: Inferred from direct assay
35087169 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
29813070 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9120401 MGI
acts upstream of or within cellular response to biotic stimulus IDA
IDA: Inferred from direct assay
23262141 MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus IDA
IDA: Inferred from direct assay
21072211 MGI
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20547752 MGI
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
29813070 MGI
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
9120401 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
16481354 MGI
involved in liver development IMP
IMP: Inferred from mutant phenotype
7603567 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
22244329 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
22244329 MGI
acts upstream of or within negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15923614 MGI
involved in negative regulation of protein sumoylation IDA
IDA: Inferred from direct assay
25152367 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25152367 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14568984 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21131967 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18505784 MGI
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
22244329 MGI
acts upstream of positive regulation of amyloid-beta formation IDA
IDA: Inferred from direct assay
21329555 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
22244329 MGI
acts upstream of or within positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
14568984 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21329555 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15923614 MGI
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
21131967 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24501220 MGI
acts upstream of or within response to bacterium IDA
IDA: Inferred from direct assay
15661922 MGI
acts upstream of or within response to muramyl dipeptide IDA
IDA: Inferred from direct assay
12527755 MGI
acts upstream of or within response to muscle stretch IDA
IDA: Inferred from direct assay
20442316 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
part of NF-kappaB p50/p65 complex IDA
IDA: Inferred from direct assay
2001591 MGI
located in chromatin IDA
IDA: Inferred from direct assay
25152367 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11567019 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11931770 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10227969 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
2001591 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rela Protein Structure

RHD-n_RelA

RHD-n_RelA: cd07885 (18 - 186)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (193 - 289)

PHA03247

PHA03247: cl33720 (254 - 520)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 549 a.a.
Protein Preferred Names Protein Names

transcription factor p65

  • avian reticuloendotheliosis viral (v-rel) oncogene homolog A

  • nuclear factor NF-kappa-B p65 subunit

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-170316 Ibetazol Inhibitor 99.80% Unkown
HY-174864 JP-163-16 99.20% Unkown
HY-N2441 Methylophiopogonone A Inhibitor 99.84% Unkown
HY-N7043 Isosilybin A 99.63% Unkown
HY-RS11827 Rela Mouse Pre-designed siRNA Set A / Unkown
HY-121309 Doxorubicinone Inhibitor 98.29% Unkown
HY-RS11826 RELA Human Pre-designed siRNA Set A / Unkown
HY-101512D rel-A-395 hydrochloride Inhibitor / Unkown
HY-174865 MMH-165-26 / Unkown
HY-RS11828 Rela Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Rela NCBI NCBI:5970