USP22 - ubiquitin specific peptidase 22 Gene

Also Known as USP3L

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23326

About USP22

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:20,999,596-21,043,419 (from NCBI)

This gene has 11 transcripts (splice variants), 221 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues.

Summary

Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent Deubiquitinase. Contributes to H4 Histone Acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]

USP22 Products (1)

mRNA	Protein	Name
NM_015276.2	NP_056091.1	ubiquitin carboxyl-terminal hydrolase 22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	16378762	GOA
contributes to cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	18206973	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables histone H2A deubiquitinase activity	IDA IDA: Inferred from direct assay	18469533	GOA
enables histone H2B deubiquitinase activity	IDA IDA: Inferred from direct assay	18469533	GOA
contributes to histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	18206973	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	18206972	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18206972	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	18206972	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	27030811	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18206973	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18206973	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	32130408	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	16378762	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of SAGA complex	IDA IDA: Inferred from direct assay	18206972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP22 Protein Structure

zf-UBP

UCH

0
100
200
300
400
500
525 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 22	deubiquitinating enzyme 22

USP22 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	USP22	Q9UPT9	FUBP1	Homo sapiens	Q96AE4	Anti Tag CoIP	21779003
Intra	USP22	Q9UPT9	AASDHPPT	Homo sapiens	Q9NRN7	Validated Y2H	25416956
Intra	USP22	Q9UPT9	AASDHPPT	Homo sapiens	Q9NRN7	Y2H Array	25416956
Intra	USP22	Q9UPT9	AASDHPPT	Homo sapiens	Q9NRN7	Anti Tag CoIP	19615732

Cross: Cross-species interaction Intra: Intraspecies interaction

USP22 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81589	USP22 Antibody (YA1334)	WB, ICC/IF, IP, FC	Human

Diseases	Alias
Glandular Tularemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS15533	USP22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16944	Usp22 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23387	Usp22 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	USP22	RGD	RGD:1310354
Bos taurus	USP22	VGNC	VGNC:36716
Canis familiaris	USP22	VGNC	VGNC:55013
Macaca mulatta	USP22	VGNC	VGNC:78742
Felis catus	USP22	VGNC	VGNC:66873
Mus musculus	USP22	MGD	MGI:2144157
Others	USP22	NCBI