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ARIH1 - ariadne RBR E3 ubiquitin protein ligase 1 Gene

Also Known as ARI; HARI; HHARI; UBCH7BP

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 25820

About ARIH1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:72,474,330-72,602,987 (from NCBI)

This gene has 10 transcripts (splice variants), 231 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 22.0), thyroid (RPKM 13.4) and 25 other tissues.

Summary

Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ARIH1 Products (1)

mRNA	Protein	Name
NM_005744.5	NP_005735.2	E3 ubiquitin-protein ligase ARIH1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	10521492	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: Inferred from physical interaction	23707686	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11278816	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14623119	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15236971	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14623119	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
NOT part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	27565346	GOA
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
located in Lewy body	IDA IDA: Inferred from direct assay	21590270	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24076655	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11278816	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	23059369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARIH1 Protein Structure

zf-C3HC4_2

IBR

0
100
200
300
400
500
557 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase ARIH1	ARI-1

ARIH1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	ITC	23707686
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	Pull Down	21532592
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	GMS	23707686
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	24076655
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	28514442
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	24076655
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	33961781
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-164476	ES-072		98.05%	Unkown
HY-RS00975	ARIH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20856	Arih1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27371	Arih1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	ARIH1	MGD	MGI:1344363
Felis catus	ARIH1	VGNC	VGNC:68178
Macaca mulatta	ARIH1	VGNC	VGNC:84308
Rattus norvegicus	ARIH1	RGD	RGD:1308131
Bos taurus	ARIH1	VGNC	VGNC:26133
Canis familiaris	ARIH1	VGNC	VGNC:38102
Others	ARIH1	NCBI