GPM6A - glycoprotein M6A Gene

Also Known as M6A; GPM6

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2823

About GPM6A

Cytogenetic location: 4q34.2 Genomic coordinates (GRCh38): 4:175,632,937-176,002,691 (from NCBI)

This gene has 21 transcripts (splice variants), 289 orthologues and 2 paralogues. Biased expression in brain (RPKM 247.1) and lung (RPKM 8.5).

Summary

Predicted to enable Calcium Channel activity. Involved in neuron migration and stem cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GPM6A Products (7)

mRNA Protein Name
NM_001261447.1 NP_001248376.1 neuronal membrane glycoprotein M6-a isoform 2
NM_001261448.1 NP_001248377.1 neuronal membrane glycoprotein M6-a isoform 4
NM_001388090.1 NP_001375019.1 neuronal membrane glycoprotein M6-a isoform 5
NM_001388091.1 NP_001375020.1 neuronal membrane glycoprotein M6-a isoform 5
NM_005277.5 NP_005268.1 neuronal membrane glycoprotein M6-a isoform 1
NM_201591.3 NP_963885.1 neuronal membrane glycoprotein M6-a isoform 1
NM_201592.3 NP_963886.1 neuronal membrane glycoprotein M6-a isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in neuron migration IDA
IDA: Inferred from direct assay
19298174 GOA
involved in stem cell differentiation IDA
IDA: Inferred from direct assay
19298174 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPM6A Protein Structure

Myelin_PLP

Myelin_PLP: Myelin proteolipid protein (PLP or lipophilin) (13 - 254)

  • 0
  • 100
  • 200
  • 278 a.a.
Protein Preferred Names Protein Names

neuronal membrane glycoprotein M6-a

GPM6A Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
GPM6A P51674 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
GPM6A P51674 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
GPM6A P51674 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
GPM6A P51674 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra
GPM6A P51674 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra
GPM6A P51674 ZDHHC17 Homo sapiens Q8IUH5
IF
24705354
Intra
GPM6A P51674 ICAM5 Homo sapiens Q9UMF0
Validated Y2H
32814053
Intra
GPM6A P51674 ICAM5 Homo sapiens Q9UMF0
Y2H Array
32814053
Intra
GPM6A P51674 ICAM5 Homo sapiens Q9UMF0
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Retinitis Pigmentosa 29

  • RP29
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05643 GPM6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22535 Gpm6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29055 Gpm6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus GPM6A MGD MGI:107671
Macaca mulatta GPM6A VGNC VGNC:73121
Felis catus GPM6A VGNC VGNC:67411
Bos taurus GPM6A VGNC VGNC:97275
Rattus norvegicus GPM6A RGD RGD:631368
Canis familiaris GPM6A VGNC VGNC:41385
Others GPM6A NCBI