ARSI - arylsulfatase family member I Gene

Also Known as ASI; SPG66

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 340075

About ARSI

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,296,343-150,302,905 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues, 16 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 1.9), placenta (RPKM 1.8) and 20 other tissues.

Summary

This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]

ARSI Products (1)

mRNA	Protein	Name
NM_001012301.4	NP_001012301.1	arylsulfatase I precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARSI Protein Structure

Sulfatase

0
100
200
300
400
500
569 a.a.

Protein Preferred Names	Protein Names
arylsulfatase I

ARSI Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ARSI	Q5FYB1	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Autosomal Recessive Spastic Paraplegia Type 66	Spg66
Spastic Paraplegia 63, Autosomal Recessive	SPG63 Hereditary Spastic Paraplegia 63 Spastic Paraplegia 63 Autosomal Recessive Spastic Paraplegia 63 Autosomal Recessive Spastic Paraplegia Type 63 Paraplegia, Spastic, Type 63, Autosomal Recessive
Noonan Syndrome 8	NS8 Noonan Syndrome, Type 8
Spastic Paraplegia 78, Autosomal Recessive	SPG78 Autosomal Recessive Spastic Paraplegia Type 78 Hereditary Spastic Paraplegia 78 Spastic Paraplegia 78 Autosomal Recessive Doid:0112348
Gastric Dilatation	Stomach Dilatation
Alternating Exotropia	Exotropia
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS01040	ARSI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	ARSI	MGD	MGI:2670959
Rattus norvegicus	ARSI	RGD	RGD:1310242
Canis familiaris	ARSI	VGNC	VGNC:38144
Macaca mulatta	ARSI	VGNC	VGNC:69937
Bos taurus	ARSI	VGNC	VGNC:26177
Felis catus	ARSI	VGNC	VGNC:59948
Others	ARSI	NCBI