KEL - Kell metallo-endopeptidase (Kell blood group) Gene

Also Known as ECE3; Kell; CD238

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 3792

About KEL

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:142,941,114-142,962,363 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 143 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 20.5), bone marrow (RPKM 20.3) and 2 other tissues.

Summary

This gene encodes a type II Transmembrane Glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the Neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]

KEL Products (1)

mRNA	Protein	Name
NM_000420.3	NP_000411.1	kell blood group glycoprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	15769748	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7737196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KEL Protein Structure

Peptidase_M13_N

Peptidase_M13

0
200
400
600
732 a.a.

Protein Preferred Names	Protein Names
kell blood group glycoprotein	Kell blood group, metallo-endopeptidase

KEL Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	KEL	P23276	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	KEL	P23276	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	KEL	P23276	PM20D2	Homo sapiens	Q8IYS1	Y2H Array	32296183
Intra	KEL	P23276	PM20D2	Homo sapiens	Q8IYS1	Y2H Prey Pooling	32296183
Intra	KEL	P23276	PM20D2	Homo sapiens	Q8IYS1	Validated Y2H	32296183
Intra	KEL	P23276	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	KEL	P23276	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	KEL	P23276	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	KEL	P23276	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	KEL	P23276	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	KEL	P23276	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	KEL	P23276	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	KEL	P23276	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
Intra	KEL	P23276	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053
Intra	KEL	P23276	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KEL Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70324	KEL/Kelch-like protein 41 Protein, Human (HEK293, His, solution)	P23276 (N68-W732)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70324A	KEL/Kelch-like protein 41 Protein, Human (HEK293, C-His)	P23276 (N68-W732)	≥ 95%, as determined by reducing SDS-PAGE.

KEL 抗体

製品番号	製品名	アプリケーション	反応性
HY-P811219	CD238 Antibody	WB, IHC-P	Human, Mouse

関連疾患

Diseases	Alias
Blood Group--Kell System	KEL Blood Group--Kell-Cellano System Blood Group, Kell Kell Blood Group System Kell Blood Group Blood Group System, Kell
Mcleod Syndrome	Mcleod Neuroacanthocytosis Syndrome MLS X-Linked Mcleod Syndrome Mcleod Phenotype Neuroacanthocytosis, Mcleod Type Mcleod Syndrome With Or Without Chronic Granulomatous Disease MCLDS Mcleod Type Neuroacanthocytosis Mcleod Syndrome With Chronic Granulomatous Disease Neuroacanthocytosis Mcleod Type Blood Group Deletion Syndrome
Neuroacanthocytosis	Neuroacanthocytosis Syndrome
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Blood Group Incompatibility
Fetal Erythroblastosis	Erythroblastosis, Fetal Ef - Erythroblastosis Foetalis Erythroblastosis Fetalis Haemolytic Disease Due To Rhesus Isoimmunisation Rhesus Isoimmunisation Of The Newborn
Neonatal Anemia	Anemia Neonatal Anemia, Neonatal Anaemia Neonatal Neonatal Anaemia
Choreoacanthocytosis	Chorea-Acanthocytosis CHAC Acanthocytosis With Neurologic Disorder Levine-Critchley Syndrome Choreaacanthocytosis Chorea Acanthocytosis Neuroacanthocytosis Levine-Critchley Syndrome, Formerly Neuroacanthocytosis, Formerly Choreo-Acanthocytosis Acanthocytosis Chorea Chorea Acanthocytosis Syndrome
Granulomatous Disease, Chronic, X-Linked	CGDX Chronic Granulomatous Disease, X-Linked X-Linked Chronic Granulomatous Disease Cgd Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked Cdgx X-Linked Chronic Cytochrome B-Negative Granulomatous Disease Chronic Granulomatous Disease Cytochrome B-Negative X-Linked Chronic Granulomatous Disease Cytochrome B-Positive X-Linked Granulomatous Disease, Chronic, X-Linked, Variant
Lingual-Facial-Buccal Dyskinesia	Orofacial Dyskinesia Oro-Facial Dyskinesia Dyskinesias
Beta-Thalassemia Major	Cooley'S Anemia Cooley Anemia Mediterranean Anemia
Hemoglobinopathy	Hemoglobinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-139039	BSJ-4-116	Inhibitor	99.87%	Unkown
HY-145765	JQAD1		98.24%	Unkown
HY-123919	TL13-112	Inhibitor	98.01%	Unkown
HY-122822	GSK699		98.80%	Unkown
HY-168439	HLB-0532259		98.30%	Unkown
HY-122582	TL13-12	Degrader	98.16%	Unkown
HY-134983	Thalidomide-Piperazine 5-fluoride	Inducer	96.47%	Unkown
HY-137343	DB-0646	Degrader	98.0%	Unkown
HY-155962	Tubulin polymerization-IN-47	Inhibitor	99.51%	Unkown
HY-172609	SL-176		99.91%	Unkown
HY-158062	LC-1-40		/	Unkown
HY-138794G	XL177A (GMP)	Inhibitor	/	Unkown
HY-155963	Tubulin polymerization-IN-48	Inhibitor	/	Unkown
HY-175599	Z6466608628		/	Unkown
HY-175599A	Z6466608628 hydrochloride		99.25%	Unkown
HY-175601	DD-04-038	Degrader	/	Unkown
HY-175602	TM-04-064-02	Degrader	/	Unkown
HY-RS07233	KEL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19110	Kel Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25600	Kel Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	KEL	RGD	RGD:1565470
Canis familiaris	KEL	VGNC	VGNC:42333
Bos taurus	KEL	VGNC	VGNC:30538
Macaca mulatta	KEL	VGNC	VGNC:81628
Mus musculus	KEL	MGD	MGI:1346053
Felis catus	KEL	VGNC	VGNC:80604
Others	KEL	NCBI