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ARHGAP5 - Rho GTPase activating protein 5 Gene

Also Known as GFI2; p190-B; RhoGAP5; p190BRhoGAP

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 394

About ARHGAP5

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:32,075,880-32,159,728 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 87 phenotypes. Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues.

Summary

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate Cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP5 Products (2)

mRNA	Protein	Name
NM_001030055.2	NP_001025226.1	rho GTPase-activating protein 5 isoform a
NM_001173.3	NP_001164.2	rho GTPase-activating protein 5 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	1689011	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23622247	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP5 Protein Structure

Ras

RhoGAP

0
300
600
900
1200
1502 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 5	growth factor independent 2

ARHGAP5 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Cross	ARHGAP5	Q13017	Rnd3	Mus musculus	P61588	Anti Tag CoIP	23622247

Cross: Cross-species interaction Intra: Intraspecies interaction

ARHGAP5 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83074	RhoGAP Antibody (YA2819)	WB, IHC-P, FC	Human, Mouse, Rat

関連疾患

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS00939	ARHGAP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	ARHGAP5	VGNC	VGNC:70008
Rattus norvegicus	ARHGAP5	RGD	RGD:1308507
Bos taurus	ARHGAP5	VGNC	VGNC:26098
Canis familiaris	ARHGAP5	VGNC	VGNC:38067
Felis catus	ARHGAP5	VGNC	VGNC:68119
Mus musculus	ARHGAP5	MGD	MGI:1332637
Others	ARHGAP5	NCBI