CD207 - CD207 molecule Gene

Also Known as CLEC4K

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 50489

About CD207

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,824,130-70,835,816 (from NCBI)

This gene has 1 transcript (splice variant), 877 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in skin (RPKM 26.1), esophagus (RPKM 6.2) and 1 other tissue.

Summary

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

CD207 Products (1)

mRNA Protein Name
NM_015717.5 NP_056532.4 C-type lectin domain family 4 member K

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables carbohydrate binding IDA
IDA: Inferred from direct assay
20026605 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25910212 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in defense response to virus IDA
IDA: Inferred from direct assay
17334373 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD207 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (213 - 321)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member K

  • C-type lectin domain family 4, member K

CD207 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Array
32296183
Intra
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Prey Pooling
32296183
Intra
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Validated Y2H
25910212
Intra
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Bait-Prey Pool
25910212
Intra
CD207 Q9UJ71 GRAMD2B Homo sapiens Q96HH9
Y2H Array
25910212
Intra
CD207 Q9UJ71 CREB3 Homo sapiens O43889-2
Validated Y2H
25910212
Intra
CD207 Q9UJ71 CREB3 Homo sapiens O43889-2
Y2H Bait-Prey Pool
25910212
Intra
CD207 Q9UJ71 CREB3 Homo sapiens O43889-2
Y2H Array
25910212
Intra
CD207 Q9UJ71 ZCCHC12 Homo sapiens Q6PEW1
Y2H Prey Pooling
32296183
Intra
CD207 Q9UJ71 ZCCHC12 Homo sapiens Q6PEW1
Y2H Array
32296183
Intra
CD207 Q9UJ71 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CD207 Q9UJ71 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CD207 Q9UJ71 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD207 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7819 Langerin/CD207 Protein, Human (HEK293, His) AAH22278.1 (Y64-P328) ≥ 95%, as determined by reducing SDS-PAGE.

CD207 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81521 Langerin Antibody (YA1266) IHC-P Human
HY-P81521A Langerin Antibody (YA1266)(PBS only) IHC-P Human

関連疾患

Diseases Alias
Birbeck Granule Deficiency

  • Birbeck Granules, Absence Of

  • BIRGD

  • Absence Of Birbeck Granules
Langerhans Cell Sarcoma

  • Malignant Langerhans Cell Sarcoma
Histiocytosis

  • Chronic Histiocytosis X

  • Hand Schuller Christian Disease

  • Hand-Schüller-Christian Disease

  • Histiocytic Syndrome

  • Histiocytosis, Langerhans-Cell
Langerhans Cell Histiocytosis

  • Histiocytosis X

  • Lch

  • Langerhans Cell Granulomatosis

  • Langerhans-Cell Histiocytosis

  • Letterer-Siwe Disease

  • Hashimoto-Pritzger Disease

  • Histiocytosis, Langerhans-Cell

  • Langerhan'S Cell Histiocytosis

  • Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes

  • Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes

  • Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes

  • Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb

  • Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck

  • Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck

  • Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb

  • Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites

  • Letterer-Siwe Disease Involving Spleen

  • Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes

  • Letterer-Siwe Disease Of Intrapelvic Lymph Nodes

  • Letterer-Siwe Disease Of Intrathoracic Lymph Nodes

  • Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb

  • Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb

  • Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck

  • Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck

  • Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb

  • Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb

  • Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites

  • Letterer-Siwe Disease Of Spleen

  • Familial Letterer-Siwe Disease

  • Langerhans-Cell Histiocytosis Nos
Follicular Dendritic Cell Sarcoma

  • Dendritic Cell Sarcoma

  • Dendritic Cell Sarcoma, Follicular

  • Follicular Dendritic Cell Tumour

  • Dendritic Cell Sarcoma, Interdigitating

  • Dendritic Cell Sarcoma, Not Otherwise Specified
Non-Langerhans-Cell Histiocytosis

  • Histiocytosis, Non-Langerhans-Cell

  • Non-Langerhans Cell Histiocytosis
Reticulohistiocytic Granuloma

  • Reticulohistiocytoma

  • Solitary Reticulohistiocytoma

  • Solitary Histiocytoma

  • Solitary Reticulohistiocytosis
Histiocytic And Dendritic Cell Cancer

  • Histiocytic And Dendritic Cell
Juvenile Xanthogranuloma

  • Multiple Eruptive Juvenile Xanthogranuloma

  • Naevoxanthoendothelioma

  • Xanthoma Neviforme

  • Xanthogranuloma, Juvenile
Vulvar Proximal-Type Epithelioid Sarcoma
Central Epithelioid Sarcoma

  • Proximal-Type Epithelioid Sarcoma
Adult Xanthogranuloma
Interdigitating Dendritic Cell Sarcoma

  • Interdigitating Cell Sarcoma

  • Dendritic Cell Sarcoma, Interdigitating

  • Reticulum Cell Sarcoma
Frontal Sinus Benign Neoplasm

  • Neoplasm Of Frontal Sinus

  • Tumor Of The Frontal Sinus
Seborrheic Dermatitis

  • Seborrhoeic Dermatitis

  • Seborrhea

  • Seborrhoeic Eczema

  • Skin Seborrheic

  • Dermatitis, Seborrheic
Beach Ear

  • Acute Swimmer'S Ear

  • Acute Bacterial Inflammation Of External Ear

  • Acute Otitis Externa, Diffuse

  • Acute Swimmers' Ear

  • Tank Ear
Rhinoscleroma
Fibrosarcoma Of Bone

  • Malignant Histiocytosis

  • Malignant Fibroxanthoma

  • Malignant Fibrous Histiocytoma

  • Histiocytic Medullary Reticulosis

  • Nasal Type Extranodal Nk/T-Cell Lymphoma

  • Histiocytic Sarcoma
Cavernous Sinus Meningioma

  • Meningioma Of The Cavernous Sinus
Otorrhea

  • Discharging Ear
Malignant Histiocytic Disease

  • Histiocytic Disorders, Malignant
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02208 CD207 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18651 Cd207 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25137 Cd207 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus CD207 VGNC VGNC:27011
Rattus norvegicus CD207 RGD RGD:1565913
Felis catus CD207 VGNC VGNC:60596
Mus musculus CD207 MGD MGI:2180021
Canis familiaris CD207 VGNC VGNC:54285
Macaca mulatta CD207 VGNC VGNC:70818
Others CD207 NCBI