SYCP3 - synaptonemal complex protein 3 Gene

Also Known as COR1; SCP3; SPGF4; RPRGL4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 50511

About SYCP3

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,728,648-101,739,462 (from NCBI)

This gene has 5 transcripts (splice variants), 327 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 35.2), duodenum (RPKM 4.0) and 14 other tissues.

Summary

This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

SYCP3 Products (3)

mRNA Protein Name
NM_001177948.2 NP_001171419.1 synaptonemal complex protein 3
NM_001177949.2 NP_001171420.1 synaptonemal complex protein 3
NM_153694.5 NP_710161.1 synaptonemal complex protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in sperm DNA condensation IMP
IMP: Inferred from mutant phenotype
14643120 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
22899867 GOA
located in synaptonemal complex IDA
IDA: Inferred from direct assay
9774970 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYCP3 Protein Structure

Cor1

Cor1: Cor1/Xlr/Xmr conserved region (82 - 211)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

synaptonemal complex protein 3

SYCP3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SYCP3 Q8IZU3 BLK Homo sapiens P51451
Anti Tag CoIP
33961781
Intra
SYCP3 Q8IZU3 BLK Homo sapiens P51451
Anti Tag CoIP
28514442
Intra
SYCP3 Q8IZU3 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
SYCP3 Q8IZU3 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SYCP3 抗体

製品番号 製品名 アプリケーション 反応性
HY-P84668 SYCP3 Antibody (YA4365) IHC-P, FC, ELISA Human
HY-P84668A SYCP3 Antibody (YA4365)(PBS only) IHC-P, FC, ELISA Human
HY-P85465 SYCP3 Antibody (YA5157) WB Human

関連疾患

Diseases Alias
Spermatogenic Failure 4

  • Spermatogenesis Arrest

  • SPGF4

  • Azoospermia Due To Perturbations Of Meiosis

  • Azoospermia With Maturation Arrest

  • Pregnancy Loss, Recurrent, 4

  • Arrest Of Spermatogenesis

  • RPRGL4

  • Recurrent Pregnancy Loss 4
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Branchiootorenal Syndrome 2

  • BOR2

  • Bor Syndrome 2

  • Branchiootorenal Dysplasia 2

  • Branchio-Oto-Renal Dysplasia 2

  • Branchio-Oto-Renal Syndrome Type 2

  • Branchiootorenal Syndrome, Type 2
Infertility
Spermatogenic Failure, X-Linked, 1

  • Sertoli Cell-Only Syndrome

  • Germinal Cell Aplasia

  • Del Castillo Syndrome

  • SPGFX1

  • X-Linked Spermatogenic Failure 1

  • Congenital Absence Of Germinal Epithelium Of Testes
Gemistocytic Astrocytoma

  • Gemistocytic Astrocytic Tumor
Autoimmune Cardiomyopathy
Spermatogenic Failure 10

  • SPGF10

  • Spermatogenic Failure With Defective Sperm Annulus
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Oligospermia
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14072 SYCP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21776 Sycp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28293 Sycp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SYCP3 MGD MGI:109542
Rattus norvegicus SYCP3 RGD RGD:3795
Bos taurus SYCP3 VGNC VGNC:56229
Others SYCP3 NCBI