PCP4 - Purkinje cell protein 4 Gene

Also Known as PEP-19

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5121

About PCP4

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,867,438-39,929,392 (from NCBI)

This gene has 4 transcripts (splice variants), 166 orthologues and 1 paralogue. Biased expression in prostate (RPKM 108.8), urinary bladder (RPKM 73.3) and 6 other tissues.

Summary

Enables calcium ion binding activity and Calmodulin binding activity. Involved in Calmodulin dependent kinase signaling pathway and positive regulation of neuron differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Biomarker of Huntington's disease and leiomyoma. [provided by Alliance of Genome Resources, Apr 2022]

PCP4 Products (1)

mRNA Protein Name
NM_006198.3 NP_006189.2 calmodulin regulator protein PCP4
Protein Preferred Names Protein Names

calmodulin regulator protein PCP4

  • brain specific polypeptide PEP19

PCP4 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PCP4 P48539 CALML6 Homo sapiens Q8TD86
Y2H Prey Pooling
32296183
Intra
PCP4 P48539 CALML6 Homo sapiens Q8TD86
Validated Y2H
32296183
Intra
PCP4 P48539 CALML6 Homo sapiens Q8TD86
Y2H Array
32296183
Intra
PCP4 P48539 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Leiomyoma

  • Leiomyomatous Neoplasm

  • Leiomyomatous Tumor

  • Leiomyomas

  • Fibroid Tumor

  • Uterine Fibroids
Autoimmune Atherosclerosis
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10168 PCP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10169 PCP4L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22273 Pcp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28796 Pcp4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta PCP4 VGNC VGNC:84749
Felis catus PCP4 VGNC VGNC:102802
Mus musculus PCP4 MGD MGI:97509
Rattus norvegicus PCP4 RGD RGD:3271
Canis familiaris PCP4 VGNC VGNC:44319
Bos taurus PCP4 VGNC VGNC:106858
Others PCP4 NCBI