RNF125 - ring finger protein 125 Gene

Also Known as TNORS; TRAC1; TRAC-1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 54941

About RNF125

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,018,825-32,088,144 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 4.1), bone marrow (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a novel E3 ubiquitin Ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

RNF125 Products (1)

mRNA	Protein	Name
NM_017831.4	NP_060301.2	E3 ubiquitin-protein ligase RNF125

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables p53 binding	IPI IPI: Inferred from physical interaction	25591766	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17460044	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: Inferred from physical interaction	27411375	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	17460044	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	27411375	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of RIG-I signaling pathway	IDA IDA: Inferred from direct assay	17460044	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	17460044	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	27411375	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17460044	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi membrane	IDA IDA: Inferred from direct assay	17990982	GOA
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: Inferred from direct assay	26471729	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	17990982	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF125 Protein Structure

zf-RING_2

zf-Di19

0
100
200
232 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF125	T-cell RING activation protein 1

RNF125 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RNF125	Q96EQ8	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786-1	Anti Bait CoIP	17460044
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786-1	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	UBE2E2	Homo sapiens	Q96LR5	Y2H	17460044
Intra	RNF125	Q96EQ8	UBE2E2	Homo sapiens	Q96LR5	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	VCP	Homo sapiens	P55072	Pull Down	26471729
Intra	RNF125	Q96EQ8	VCP	Homo sapiens	P55072	Anti Bait CoIP	26471729
Intra	RNF125	Q96EQ8	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786	Anti Bait CoIP	26471729
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786	Pull Down	26471729

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Tenorio Syndrome	TNORS Overgrowth, Macrocephaly, And Intellectual Disability Syndrome
Neuronopathy, Distal Hereditary Motor, Type Iid	HMN2D Hmn Iid Dhmn2d Distal Hereditary Motor Neuronopathy Type 2d Distal Hereditary Motor Neuropathy Type Iid Neuronopathy, Distal Hereditary Motor, Type 2d Neuropathy, Distal Hereditary Motor, Type Iid Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant Distal Spinal Muscular Atrophy With Calf Predominance Neuronopathy, Distal Hereditary Motor, 2d Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant Dhmn Iid Neuropathy, Motor, Distal, Hereditary, Type 2d
Distal Hereditary Motor Neuronopathy Type 2	Distal Hereditary Motor Neuropathy, Type Ii Distal Hereditary Motor Neuropathy Type 2 Distal Hereditary Motor Neuropathy Type Ii Hmn Ii Hmn2 Distal Hereditary Motor Neuronopathy, Type Ii Distal Spinal Muscular Atrophy Type 2 Dhmn2 Dsma2 Neuropathy, Motor, Distal, Hereditary, Type Ii Spinal Muscular Atrophy, Jerash Type
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12044	RNF125 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	RNF125	RGD	RGD:1306757
Felis catus	RNF125	VGNC	VGNC:64667
Mus musculus	RNF125	MGD	MGI:1914914
Canis familiaris	RNF125	VGNC	VGNC:45627
Macaca mulatta	RNF125	VGNC	VGNC:104244
Bos taurus	RNF125	VGNC	VGNC:34017
Others	RNF125	NCBI