SLC41A3 - solute carrier family 41 member 3 Gene

Also Known as SLC41A1-L2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 54946

About SLC41A3

Cytogenetic location: 3q21.2-q21.3 Genomic coordinates (GRCh38): 3:126,006,357-126,101,520 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 23.3), ovary (RPKM 19.3) and 25 other tissues.

Summary

Predicted to enable cation transmembrane transporter activity. Predicted to be involved in cation transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC41A3 Products (5)

mRNA	Protein	Name
NM_001008485.2	NP_001008485.2	solute carrier family 41 member 3 isoform 1
NM_001008486.2	NP_001008486.2	solute carrier family 41 member 3 isoform 3
NM_001008487.2	NP_001008487.1	solute carrier family 41 member 3 isoform 4
NM_001164475.2	NP_001157947.1	solute carrier family 41 member 3 isoform 5
NM_017836.4	NP_060306.4	solute carrier family 41 member 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables magnesium:sodium antiporter activity	IDA IDA: Inferred from direct assay	27302215	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in mitochondrial magnesium ion transmembrane transport	IDA IDA: Inferred from direct assay	27302215	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	27302215	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC41A3 Protein Structure

MgtE

0
100
200
300
400
507 a.a.

Protein Preferred Names	Protein Names
solute carrier family 41 member 3	SLC41A1-like 2

SLC41A3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SLC41A3	Q96GZ6	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	SLC41A3	Q96GZ6	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	SLC41A3	Q96GZ6	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	SLC41A3	Q96GZ6	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	SLC41A3	Q96GZ6	SUFU	Homo sapiens	Q9UMX1	Y2H Prey Pooling	32296183
Intra	SLC41A3	Q96GZ6	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183
Intra	SLC41A3	Q96GZ6	SUFU	Homo sapiens	Q9UMX1	Y2H Array	32296183
Intra	SLC41A3	Q96GZ6	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	SLC41A3	Q96GZ6	NHERF4	Homo sapiens	Q86UT5	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Hypomagnesemia 1, Intestinal	Intestinal Hypomagnesemia 1 HOMG1 Hypomagnesemia With Secondary Hypocalcemia Hsh Hypomagnesemic Tetany Intestinal Hypomagnesemia With Secondary Hypocalcemia Homg Hypomagnesemia Caused By Selective Magnesium Malabsorption Hypomagnesemia Intestinal Type 1 Primary Hypomagnesemia With Secondary Hypocalcemia Phsh Hypomagnesemia, Intestinal, With Secondary Hypocalcemia Familial Primary Hypomagnesemia With Hypocalcuria Hypomagnesemia 1 Hypomagnesmic Tetany
Primary Hypomagnesemia	Familial Primary Hypomagnesemia Homg Primary Familial Hypomagnesemia Genetic Primary Hypomagnesemia Hypomagnesemia 1, Intestinal
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS13247	SLC41A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	SLC41A3	VGNC	VGNC:46414
Bos taurus	SLC41A3	VGNC	VGNC:58412
Rattus norvegicus	SLC41A3	RGD	RGD:1589573
Mus musculus	SLC41A3	MGD	MGI:1918949
Macaca mulatta	SLC41A3	VGNC	VGNC:77586
Others	SLC41A3	NCBI