EAPP - E2F associated phosphoprotein Gene

Also Known as BM036; C14orf11

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 55837

About EAPP

Cytogenetic location: 14q13.1 Genomic coordinates (GRCh38): 14:34,515,938-34,539,701 (from NCBI)

This gene has 4 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in bone marrow (RPKM 22.0), colon (RPKM 18.0) and 25 other tissues.

Summary

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during Mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

EAPP Products (2)

mRNA Protein Name
NM_001318916.2 NP_001305845.1 E2F-associated phosphoprotein isoform 2
NM_018453.4 NP_060923.2 E2F-associated phosphoprotein isoform 1

EAPP Protein Structure

Eapp_C

Eapp_C: E2F-associated phosphoprotein (138 - 283)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

E2F-associated phosphoprotein

EAPP Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
EAPP Q56P03 AAR2 Homo sapiens Q9Y312
Anti Tag CoIP
33961781
Intra
EAPP Q56P03 AAR2 Homo sapiens Q9Y312
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Holoprosencephaly 8

  • HPE8

  • Holoprosencephaly-8
Spastic Hemiplegia

  • Spastic Hemiplegic Cerebral Palsy

  • Hemiplegic Cerebral Palsy

  • Congenital Hemiplegia

  • Hemiplegic Infantile Cerebral Palsy

  • Cerebral Palsy Spastic Hemiplegic

  • Spastic Hemiplegia Cerebral Palsy

  • Hemiplegia, Spastic
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Cartilage Cancer

  • Chondrogenic Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-149209 LL-K8-22 99.06% Unkown
HY-RS04121 EAPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19894 Eapp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26395 Eapp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus EAPP MGD MGI:1913516
Macaca mulatta EAPP VGNC VGNC:108295
Felis catus EAPP VGNC VGNC:80981
Rattus norvegicus EAPP RGD RGD:1309624
Bos taurus EAPP VGNC VGNC:28296
Others EAPP NCBI