MAPK4 - mitogen-activated protein kinase 4 Gene

Also Known as ERK4; ERK-4; PRKM4; p63MAPK; p63-MAPK

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5596

About MAPK4

Cytogenetic location: 18q21.1-q21.2 Genomic coordinates (GRCh38): 18:50,559,612-50,731,826 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 207 orthologues and 19 paralogues. Biased expression in adrenal (RPKM 3.2), brain (RPKM 3.1) and 11 other tissues.

Summary

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MAPK4 Products (3)

mRNA Protein Name
NM_001292039.2 NP_001278968.1 mitogen-activated protein kinase 4 isoform 2
NM_001292040.2 NP_001278969.1 mitogen-activated protein kinase 4 isoform 3
NM_002747.4 NP_002738.2 mitogen-activated protein kinase 4 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 312)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 4

  • Erk3-related

MAPK4 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MAPK4 P31152 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
MAPK4 P31152 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-172781 HDAC6-IN-55 Inhibitor / Unkown
HY-RS08116 MAPK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17984 Mapk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19216 Mapk6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24455 Mapk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus MAPK4 RGD RGD:3047
Canis familiaris MAPK4 VGNC VGNC:42998
Mus musculus MAPK4 MGD MGI:2444559
Bos taurus MAPK4 VGNC VGNC:31220
Macaca mulatta MAPK4 VGNC VGNC:74647
Felis catus MAPK4 VGNC VGNC:68169
Others MAPK4 NCBI