SLA - Src like adaptor Gene

Also Known as SLA1; SLAP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 6503

About SLA

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,036,728-133,102,602 (from NCBI)

This gene has 23 transcripts (splice variants), 231 orthologues and 9 paralogues. Broad expression in appendix (RPKM 40.5), lymph node (RPKM 30.4) and 15 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in dendritic spine and focal adhesion. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLA Products (5)

mRNA Protein Name
NM_001045556.3 NP_001039021.1 src-like-adapter isoform a
NM_001045557.3 NP_001039022.2 src-like-adapter isoform b
NM_001282964.2 NP_001269893.1 src-like-adapter isoform d
NM_001282965.2 NP_001269894.1 src-like-adapter isoform e
NM_006748.4 NP_006739.2 src-like-adapter isoform c

SLA Protein Structure

SH3_1

SH3_1: SH3 domain (43 - 73)

SH2

SH2: SH2 domain (84 - 160)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

src-like-adapter

  • SLAP-1

SLA Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SLA Q13239 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
SLA Q13239 PDGFRB Homo sapiens P09619
CoIP
9742401
Intra
SLA Q13239 NCOA2 Homo sapiens Q15596
Anti Tag CoIP
33961781
Intra
SLA Q13239 NCOA2 Homo sapiens Q15596
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Cd3zeta Deficiency
Swine Influenza

  • Influenza Due To Influenza A Virus Subtype H1n1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-P990190 Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12680 SEPSECS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12975 SLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12976 SLA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17626 Sla Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18035 Heph Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24086 Sla Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus SLA RGD RGD:631373
Macaca mulatta SLA VGNC VGNC:77377
Canis familiaris SLA VGNC VGNC:46202
Mus musculus SLA MGD MGI:104295
Bos taurus SLA VGNC VGNC:34650
Others SLA NCBI