Ubash3b - ubiquitin associated and SH3 domain containing, B Gene

Also Known as p70; STS-1; TULA-2; 2810457I06Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 72828

Summary

Enables phosphoprotein binding activity and protein tyrosine Phosphatase activity. Involved in regulation of osteoclast differentiation. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and platelet aggregation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; incisor; limb; nasal cavity epithelium; and retina. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2022]

Ubash3b Products (2)

mRNA Protein Name
NM_001357412.1 NP_001344341.1 ubiquitin-associated and SH3 domain-containing protein B isoform 2
NM_176860.6 NP_789830.1 ubiquitin-associated and SH3 domain-containing protein B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphoprotein binding IDA
IDA: Inferred from direct assay
27609517 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24256567 MGI
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
27609517 MGI
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
23149425 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within collagen-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
27609517 MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27609517 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
23149425 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
23149425 MGI
acts upstream of or within negative regulation of platelet aggregation IMP
IMP: Inferred from mutant phenotype
20585042 MGI
acts upstream of or within negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
27609517 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
20585042 MGI
acts upstream of or within negative regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
23149425 MGI
acts upstream of or within peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
27609517 MGI
acts upstream of or within peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
20585042 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
27609517 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
27609517 MGI
involved in regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
23149425 MGI
acts upstream of or within regulation of protein binding IMP
IMP: Inferred from mutant phenotype
27609517 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
20585042 MGI
acts upstream of signal transduction IMP
IMP: Inferred from mutant phenotype
23149425 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-associated and SH3 domain-containing protein B

  • T-cell ubiquitin ligand 2

  • cbl-interacting protein p70

  • suppressor of T-cell receptor signaling 1

  • tyrosine-protein phosphatase STS1/TULA2

Ubash3b Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Cross
Ubash3b Q8BGG7 ZAP70 Homo sapiens P43403
Anti Bait CoIP
24256567
Cross
Ubash3b Q8BGG7 ZAP70 Homo sapiens P43403
Anti Tag CoIP
24256567
Cross
Ubash3b Q8BGG7 ZAP70 Homo sapiens P43403
Pull Down
24256567
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15332 UBASH3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22052 Ubash3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28570 Ubash3b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Ubash3b NCBI NCBI:84959