UBASH3B - ubiquitin associated and SH3 domain containing B Gene

Also Known as p70; STS1; STS-1; TULA2; TULA-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84959

About UBASH3B

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:122,655,722-122,814,473 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and 1 paralogue. Broad expression in spleen (RPKM 7.0), placenta (RPKM 6.8) and 18 other tissues.

Summary

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

UBASH3B Products (2)

mRNA Protein Name
NM_001363365.2 NP_001350294.1 ubiquitin-associated and SH3 domain-containing protein B isoform 2
NM_032873.5 NP_116262.2 ubiquitin-associated and SH3 domain-containing protein B isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20585042 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBASH3B Protein Structure

UBA

UBA: UBA/TS-N domain (42 - 73)

SH3_9

SH3_9: Variant SH3 domain (261 - 315)

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (386 - 583)

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  • 600
  • 649 a.a.
Protein Preferred Names Protein Names

ubiquitin-associated and SH3 domain-containing protein B

  • Cbl-interacting protein Sts-1

UBASH3B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBASH3B Q8TF42 SLC25A48 Homo sapiens Q6ZT89
Y2H Prey Pooling
25416956
Intra
UBASH3B Q8TF42 SLC25A48 Homo sapiens Q6ZT89
Y2H Array
25416956
Intra
UBASH3B Q8TF42 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
UBASH3B Q8TF42 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
UBASH3B Q8TF42 TNKS Homo sapiens O95271
Y2H Array
32296183
Intra
UBASH3B Q8TF42 TNKS Homo sapiens O95271
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
UBASH3B Q8TF42 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 EFS Homo sapiens O43281-2
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 EFS Homo sapiens O43281-2
Y2H Array
32296183
Intra
UBASH3B Q8TF42 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
UBASH3B Q8TF42 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
UBASH3B Q8TF42 PRR35 Homo sapiens P0CG20
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 PRR35 Homo sapiens P0CG20
Y2H Array
32296183
Intra
UBASH3B Q8TF42 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
UBASH3B Q8TF42 DLGAP2 Homo sapiens Q9P1A6-3
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
UBASH3B Q8TF42 CBLB Homo sapiens Q13191
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 CBLB Homo sapiens Q13191
Y2H Array
32296183
Intra
UBASH3B Q8TF42 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
Intra
UBASH3B Q8TF42 DOC2A Homo sapiens Q14183
Y2H Array
32296183
Intra
UBASH3B Q8TF42 RCHY1 Homo sapiens Q96PM5
Validated Y2H
25416956
Intra
UBASH3B Q8TF42 RCHY1 Homo sapiens Q96PM5
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 RCHY1 Homo sapiens Q96PM5
Y2H Prey Pooling
25416956
Intra
UBASH3B Q8TF42 RCHY1 Homo sapiens Q96PM5
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 DOC2A Homo sapiens Q14183
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 RCHY1 Homo sapiens Q96PM5
Y2H Array
32296183
Intra
UBASH3B Q8TF42 BBC3 Homo sapiens Q96PG8
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 CCDC74B Homo sapiens Q96LY2-2
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 CCDC74B Homo sapiens Q96LY2-2
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 CCDC74B Homo sapiens Q96LY2-2
Y2H Array
32296183
Intra
UBASH3B Q8TF42 DTX3 Homo sapiens Q8N9I9
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 DTX3 Homo sapiens Q8N9I9
Y2H Array
32296183
Intra
UBASH3B Q8TF42 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra
UBASH3B Q8TF42 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
UBASH3B Q8TF42 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 VPS37B Homo sapiens Q9H9H4
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 VPS37B Homo sapiens Q9H9H4
Y2H Array
32296183
Intra
UBASH3B Q8TF42 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
25416956
Intra
UBASH3B Q8TF42 HOXB2 Homo sapiens P14652
Y2H Array
32296183
Intra
UBASH3B Q8TF42 HOXB2 Homo sapiens P14652
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
UBASH3B Q8TF42 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra
UBASH3B Q8TF42 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
UBASH3B Q8TF42 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
UBASH3B Q8TF42 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
UBASH3B Q8TF42 SPRY2 Homo sapiens O43597
Y2H Array
25416956
Intra
UBASH3B Q8TF42 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Intra
UBASH3B Q8TF42 SYK Homo sapiens P43405
Phosphatase Assay
20585042
Intra
UBASH3B Q8TF42 SYK Homo sapiens P43405
Pull Down
20585042
Intra
UBASH3B Q8TF42 FAM168A Homo sapiens Q92567
Y2H Array
31515488
Intra
UBASH3B Q8TF42 WASL Homo sapiens O00401
Y2H Array
32296183
Intra
UBASH3B Q8TF42 WASL Homo sapiens O00401
Y2H Prey Pooling
32296183
Intra
UBASH3B Q8TF42 DMRT3 Homo sapiens Q9NQL9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBASH3B Proteins

Cat. No. Product Name Accession Purity
HY-P74484 UBASH3B/STS1 Protein, Human (His) Q8TF42 (Q382-E649) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
B-Cell Adult Acute Lymphocytic Leukemia

  • Adult B Acute Lymphoblastic Leukemia

  • Adult B Acute Lymphoblastic Leukaemia

  • Adult B-Cell Acute Lymphoblastic Leukaemia

  • Adult B-Cell Acute Lymphoblastic Leukemia

  • Adult B-Cell Lymphocytic Leukaemia

  • Adult B-Cell Lymphocytic Leukemia

  • Adult B-Lymphoblastic Leukaemia

  • Adult B-Lymphoblastic Leukemia

  • B-Cell Adult Acute Lymphocytic Leukaemia

  • B-Cell Adult Acute Lymphoblastic Leukemia
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15332 UBASH3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22052 Ubash3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28570 Ubash3b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBASH3B VGNC VGNC:36575
Felis catus UBASH3B VGNC VGNC:66756
Macaca mulatta UBASH3B VGNC VGNC:79826
Mus musculus UBASH3B MGD MGI:1920078
Rattus norvegicus UBASH3B RGD RGD:1310357
Canis familiaris UBASH3B VGNC VGNC:48048
Others UBASH3B NCBI