ST7 - suppression of tumorigenicity 7 Gene

Also Known as HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7982

About ST7

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,953,501-117,230,176 (from NCBI)

This gene has 28 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues.

Summary

The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

ST7 Products (11)

mRNA Protein Name
NM_001369598.1 NP_001356527.1 suppressor of tumorigenicity 7 protein isoform 3
NM_001369599.1 NP_001356528.1 suppressor of tumorigenicity 7 protein isoform 1
NM_001369600.1 NP_001356529.1 suppressor of tumorigenicity 7 protein isoform 2
NM_001369601.1 NP_001356530.1 suppressor of tumorigenicity 7 protein isoform 4
NM_001369602.1 NP_001356531.1 suppressor of tumorigenicity 7 protein isoform 6
NM_001369603.1 NP_001356532.1 suppressor of tumorigenicity 7 protein isoform 7
NM_001369604.1 NP_001356533.1 suppressor of tumorigenicity 7 protein isoform 9
NM_001369606.1 NP_001356535.1 suppressor of tumorigenicity 7 protein isoform 10
NM_001369607.1 NP_001356536.1 suppressor of tumorigenicity 7 protein isoform 11
NM_018412.4 NP_060882.2 suppressor of tumorigenicity 7 protein isoform 5
NM_021908.3 NP_068708.1 suppressor of tumorigenicity 7 protein isoform 8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
30945288 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST7 Protein Structure

ST7

ST7: ST7 protein (16 - 570)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 585 a.a.
Protein Preferred Names Protein Names

suppressor of tumorigenicity 7 protein

  • family with sequence similarity 4, subfamily A, member 1

関連疾患

Diseases Alias
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Gastric Dilatation

  • Stomach Dilatation
Facial Neuralgia
Neurilemmoma Of The Fifth Cranial Nerve

  • Trigeminal Schwannoma

  • Trigeminal Neurilemmoma
Trigeminal Nerve Neoplasm

  • Neoplasm Of Trigeminal Nerve

  • Tumor Of Trigeminal Nerve
Duodenal Obstruction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07795 LRP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13854 ST7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13855 ST7L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18224 St7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24701 St7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus ST7 VGNC VGNC:49974
Felis catus ST7 VGNC VGNC:65734
Macaca mulatta ST7 VGNC VGNC:77899
Rattus norvegicus ST7 RGD RGD:1303148
Mus musculus ST7 MGD MGI:1927450
Canis familiaris ST7 VGNC VGNC:49656
Others ST7 NCBI