CAPN6 - calpain 6 Gene

Also Known as CANPX; CAPNX; CalpM; DJ914P14.1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 827

About CAPN6

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,245,099-111,270,483 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 20 paralogues. Biased expression in placenta (RPKM 59.5), endometrium (RPKM 13.7) and 5 other tissues.

Summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of Other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting Apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]

CAPN6 Products (1)

mRNA Protein Name
NM_014289.4 NP_055104.2 calpain-6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17210638 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
17210638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN6 Protein Structure

Peptidase_C2

Peptidase_C2: Calpain family cysteine protease (26 - 341)

Calpain_III

Calpain_III: Calpain large subunit, domain III (358 - 494)

C2

C2: C2 domain (519 - 597)

  • 0
  • 100
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  • 500
  • 600
  • 641 a.a.
Protein Preferred Names Protein Names

calpain-6

  • calpain-like protease X-linked

CAPN6 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CAPN6 Q9Y6Q1 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
32296183
Intra
CAPN6 Q9Y6Q1 ZBTB14 Homo sapiens O43829
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CAPN6 抗体

製品番号 製品名 アプリケーション 反応性
HY-P89990 Calpain 6 Antibody (YA9334) WB, IP, FC human

関連疾患

Diseases Alias
Leiomyosarcoma

  • Leiomyosarcomas
Leiomyoma

  • Leiomyomatous Neoplasm

  • Leiomyomatous Tumor

  • Leiomyomas

  • Fibroid Tumor

  • Uterine Fibroids
Corneal Dystrophy, Endothelial, X-Linked

  • X-Linked Endothelial Corneal Dystrophy

  • XECD

  • Endothelial Corneal Dystrophy, X-Linked
Corneal Dystrophy, Posterior Polymorphous, 1

  • Posterior Polymorphous Corneal Dystrophy

  • Ppcd

  • Maumenee Corneal Dystrophy

  • Posterior Polymorphous Corneal Dystrophy 1

  • PPCD1

  • Corneal Dystrophy, Hereditary Polymorphous Posterior

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant

  • Schlichting Dystrophy

  • Ched1

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

  • Ched1, Formerly

  • Hereditary Polymorphus Posterior Corneal Dystrophy

  • Posterior Polymorphous Dystrophy

  • Hereditary Polymorphous Posterior Corneal Dystrophy

  • Dystrophy, Corneal, Posterior Polymorphous

  • Dystrophy, Corneal, Posterior Polymorphous, Type 1

  • Polymorphous Corneal Dystrophy

  • Corneal Endothelial Dystrophy 2
Deafness, X-Linked 1

  • DFNX1

  • Dfn2

  • Deafness, X-Linked 2, Sensorineural Congenital

  • X-Linked Deafness 1

  • X-Linked Sensorineural Congenital Deafness 2

  • Deafness, X-Linked, 1

  • Congenital Sensorineural Deafness X-Linked 2

  • Deafness, X-Linked, Type 1
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a

  • Leyden-Moebius Muscular Dystrophy

  • Lgmd2a

  • Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency

  • Muscular Dystrophy, Limb-Girdle, Type 2a

  • Pelvofemoral Muscular Dystrophy

  • Primary Calpainopathy
Chondroblastic Osteosarcoma

  • Chondrosarcomatous Osteogenic Sarcoma
Autosomal Recessive Limb-Girdle Muscular Dystrophy

  • Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS01892 CAPN6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus CAPN6 VGNC VGNC:26749
Mus musculus CAPN6 MGD MGI:1100850
Macaca mulatta CAPN6 VGNC VGNC:70535
Rattus norvegicus CAPN6 RGD RGD:70960
Canis familiaris CAPN6 VGNC VGNC:38706
Felis catus CAPN6 VGNC VGNC:60356
Others CAPN6 NCBI