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SELENBP1 - selenium binding protein 1 Gene

Also Known as MTO; LPSB; SP56; hSBP; EHMTO; SBP56; HEL-S-134P

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 8991

About SELENBP1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,364,304-151,372,705 (from NCBI)

This gene has 19 transcripts (splice variants), 269 orthologues and is associated with 2 phenotypes. Broad expression in colon (RPKM 232.0), lung (RPKM 124.7) and 17 other tissues.

Summary

This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing Cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of Cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

SELENBP1 Products (3)

mRNA	Protein	Name
NM_001258288.2	NP_001245217.1	methanethiol oxidase isoform 2
NM_001258289.2	NP_001245218.1	methanethiol oxidase isoform 3
NM_003944.4	NP_003935.2	methanethiol oxidase isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables methanethiol oxidase activity	IMP IMP: Inferred from mutant phenotype	29255262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENBP1 Protein Structure

SBP56

0
100
200
300
400
472 a.a.

Protein Preferred Names	Protein Names
methanethiol oxidase	56 kDa selenium-binding protein

SELENBP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SELENBP1	Q13228	MSRA	Homo sapiens	Q9UJ68	Y2H Array	32296183
Intra	SELENBP1	Q13228	MSRA	Homo sapiens	Q9UJ68	Y2H Prey Pooling	32296183
Intra	SELENBP1	Q13228	MSRA	Homo sapiens	Q9UJ68	Validated Y2H	32296183
Intra	SELENBP1	Q13228	THAP12	Homo sapiens	O43422	Y2H Prey Pooling	32296183
Intra	SELENBP1	Q13228	THAP12	Homo sapiens	O43422	Y2H Array	32296183
Intra	SELENBP1	Q13228	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	SELENBP1	Q13228	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	SELENBP1	Q13228	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	SELENBP1	Q13228	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	SELENBP1	Q13228	USP33	Homo sapiens	Q8TEY7-2	Pull Down	19118533
Intra	SELENBP1	Q13228	USP33	Homo sapiens	Q8TEY7-2	ELISA	19118533
Intra	SELENBP1	Q13228	USP33	Homo sapiens	Q8TEY7-2	IF	19118533

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Extraoral Halitosis Due To Methanethiol Oxidase Deficiency	Methanethiol Oxidase Deficiency Extraoral Halitosis Due To Mto Deficiency EHMTO Mto Deficiency Extraoral Halitosis With Dimethylsulfoxiduria Autosomal Recessive Extra-Oral Halitosis Mto-Deficiency
Methionine Adenosyltransferase Deficiency	Mat Deficiency Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Acetyl-Coa Acetyltransferase
Tyrosinemia	Hypertyrosinemia Tyrosinemias Hereditary Tyrosinemia Hypertyrosinaemia Tyrosinaemia Hereditary Hypertyrosinemia
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12633	SELENBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	SELENBP1	VGNC	VGNC:64981
Bos taurus	SELENBP1	VGNC	VGNC:34422
Canis familiaris	SELENBP1	VGNC	VGNC:45981
Macaca mulatta	SELENBP1	VGNC	VGNC:100137
Rattus norvegicus	SELENBP1	RGD	RGD:620571
Mus musculus	SELENBP1	MGD	MGI:96825
Others	SELENBP1	NCBI