HS014
Based on 1 publication(s) in Google Scholar
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 207678-81-7
- 分子式: C71H94N20O17S2
- 分子量:1563.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
![[D-Trp8]-γ-MSH](https://file.medchemexpress.com/product_pic/hy-p1217.gif)
MedChemExpress（MCE）の使用を引用している文献 HS014
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生物活性
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MC4R |
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 207678-81-7
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分子量 1563.76
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分子式 C71H94N20O17S2
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配列
Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)
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シーケンスの短縮
Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice. [Abstract]2025 Jul;46(7):1892-1904. PMID: 40011629
純度とドキュメンテーション
参考文献
[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. [Content Brief]
[2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. [Content Brief]
[3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HS014 関連分類
HY-P1216 関連分類
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