Human UGT2B7
Based on 1 Customer Validation
Human UGT2B7 is a UDP-glucuronosyltransferase isoform. Human UGT2B7 catalyzes the glucuronidation of Clopidogrel carboxylic acid (HY-141749A), Chloramphenicol (HY-B0239), and Morphine. Human UGT2B7 can be used in studies related to acute coronary syndrome and thrombus-induced events.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
UGT2B7 |
体外実験
Human UGT2B7 (50 min) efficiently catalyzes the O-glucuronidation of Chloramphenicol (HY-B0239). Its activity for producing 3-O-glucuronide (CLint = 0.43 L/min/mg protein) is higher than that for producing 1-O-glucuronide (CLint = 0.047 L/min/mg protein), and it is the only tested UGT isoform with significant 1-O-glucuronidation activity[2].
Human UGT2B7 catalyzes the glucuronidation of Morphine[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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SMILES
[Human UGT2B7]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ji JZ, et al. Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate. Biopharmaceutics & drug disposition. 2018 Feb;39(2):88-98. [Content Brief]
[2]. Chen M, et al. Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol. Drug metabolism and disposition: the biological fate of chemicals. 2010 Mar;38(3):368-75. [Content Brief]
[3]. Coffman B L, et al. Human UGT2B7 catalyzes morphine glucuronidation[J]. Drug Metabolism and Disposition, 1997, 25(1): 1-4. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Human UGT2B7 関連分類
HY-E72113 関連分類
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