Intralipid 20%
Based on 5 publication(s) in Google Scholar
Intralipid 20% is a safe fat emulsion, composed of soybean oil (consisting of a mixture of long-chain triglycerides (C14-24) of predominantly unsaturated fatty acids), and egg phospholipids, can be used as a nutritional supplement. Intralipid 20% effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 68890-65-3
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Intralipid 20%
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In Vivo Efficacy Study
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In Vivo Efficacy Study
生物活性
製品説明
体外実験
Intralipid 20% (0-0.2 mg/mL) specifically protects immune cells from paclitaxel, but has no effect on tumor cells[1].
Intralipid 20% (0-0.2 mg/mL, 3 days) promotes polarisation of M0, M1 and M2 macrophages to an M1-like phenotype[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
Intralipid pretreatment promotes the accumulation of paclitaxel in tumour tissue and induces higher levels of apoptosis in tumour cells. Increased distribution of paclitaxel in mouse RES organs and enhanced inhibition of tumour growth[1].
Intralipid (5 mL/kg) is more effective than cyclosporin-A in protecting the heart from I/R injury in SD rats, reducing the size of myocardial infarction by approximately 40%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 68890-65-3
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性状 Liquid (Density: 0.99 g/cm3)
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Color White to off-white
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SMILES
[Intralipid 20%]
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別名
20% Fat Emulsion
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice. [Abstract]2025 Jul 1;16(1):5943. PMID: 40593837
Intralipid 20% purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 1;16(1):5943. [Abstract]
Heatmaps of mouse location throughout the free-feeding tests, the consumption of three liquids (i.e., Sucrose, Water, and an Intralipid solution (1.5%)) and time spent in the corresponding zones in the CON and NCI mice.
Intralipid 20% purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 1;16(1):5943. [Abstract]
The percentage of time spent in each food zone and percentage of each type of liquid intake.
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Adv Healthc Mater
2026 Mar 6:e05668. PMID: 41793059 -
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J Biophotonics
2026 Jun;19(6):e70289. PMID: 42205110 -
プロトコル
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jingyuan Li, et al. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct;117(4):836-46. [Content Brief]
[2]. Yen-Ju Chen, et al. Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System. Sci Rep. 2020 Feb 18;10(1):2838. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Intralipid 20% 関連分類
HY-131370B 関連分類
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