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製品番号: HY-185759

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IR-19-Py

IR-19-Py is an ionizable lipid suitable for aerosolized mRNA delivery. When formulated into lipid nanoparticles, IR-19-Py delivers mRNA to nasal tissues in mice, achieving sustained nasal protein expression and dose-dependent pulmonary protein expression. IR-19-Py can be used in cystic fibrosis research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2940240-84-4
分子式: C₅₅H₁₀₁N₃O₅
分子量:884.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

IR-19-Py 構造式

CAS 番号: 2940240-84-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

IR-19-Py-containing LNP (24 h) efficiently delivers mRNA to the lung epithelial cell line A549, with an efficiency comparable to that of the control lipid C12-200 (HY-145405)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

IR-19-Py LNP (1 mg firefly luciferase mRNA; administered via nebulization; once every 72 h (repeated administration); single administration) delivers nebulized mRNA to the lungs and nasal cavities of mice, enabling long-term expression in the nasal cavity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (female, 6-8 weeks old)^[1]
Dosage:

1 mg firefly luciferase mRNA (single dose; 3 total doses)
Administration:

nebulized; every 72 hours (repeat dosing); single dose (initial)
Result:

Lasted at least 48 hours post-nebulization in lung protein expression.
Exhibited prolonged nasal luciferase expression.
Showed no loss in lung luminescence over three repeat doses administered every 72 hours.
Showed a dose-dependent increase in lung luminescence with increasing nebulized mRNA dose.

化学情報

CAS 番号 2940240-84-4
分子量 884.41
分子式 C₅₅H₁₀₁N₃O₅
SMILES

CN(CCCN1N=CC=C1)CC(CCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)C(O)CCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Jiang AY, et al. Combinatorial development of nebulized mRNA delivery formulations for the lungs. Nature nanotechnology. 2024 Mar;19(3):364-375. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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