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製品番号: HY-167655

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KF-19418

KF-19418 is a hair follicle stimulator with hair growth promoting activity. KF-19418 stimulates proliferation of cultured hair bulb cells from newborn mice. KF-19418 accelerates hair regrowth in hair-clipped mouse alopecia model following topical application. KF-19418 can be used for the research of alopecia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 147508-06-3
分子式: C₂₁H₁₄N₄O
分子量:338.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

KF-19418 構造式

CAS 番号: 147508-06-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

KF-19418 (0.001-10 μM; 4 days) concentration-dependently stimulates proliferation of hair bulb cells isolated from 4-day-old C3H/HeN mice, reaching ~240% of control growth at 10 μM over 4 days, while maintaining immature cell morphology and melanocyte populations^[1].
KF-19418 (3-10 μM; 3 days) promotes hair follicle elongation in cultured whole skin pieces from 4-week-old C3H mice in anagen phase, with 10 μM increasing tissue area by ~13% over 3 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

KF-19418 (1% suspension; topical; daily; 2 weeks) promotes hair regrowth in a mouse alopecia model, with a hair-regrown area ratio of 38.4%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H mice (8-week-old, telogen phase)^[1]
Dosage:

1% suspension
Administration:

topical; daily; 2 weeks
Result:

Reached a hair-regrown area to shaved area ratio of 38.4%.
Showed visible hair regrowth after 1 week of application.
Caused no visible skin abnormalities (e.g., inflammation).

化学情報

CAS 番号 147508-06-3
分子量 338.36
分子式 C₂₁H₁₄N₄O
SMILES

O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NN=C2C5=CC=CC=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Shirai A, et al. KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models. J Dermatol Sci. 2001;25(3):213-218. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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