KY1070
KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human
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hBMP6 0.00014 μM (Kd) |
KY1070 (starting at a final concentration of 600 nM) binds recombinant human BMP6, neutralizes BMP6 from multiple species, lacks cross-reactivity to other BMPs, and inhibits BMPR heterodimerization (Kd = 140 pM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KY1070 (0.1-3 mg/kg) increases EPO sensitivity in male C57BL/6N mice with CKD[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bmp6 wild-type mice; Bmp6-deficient mice[1]
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Dosage:3 mg/kg
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Administration:single injection
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Result:Significantly decreased hepatic Hamp mRNA and increased plasma iron levels in Bmp6-wt mice; showed no effect on hepatic Hamp mRNA or plasma iron levels in Bmp6^-/- mice
P22004
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
化学情報
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Petzer V, et al. A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease. Blood. 2020 Aug 27;136(9):1080-1090. [Content Brief]
[2]. Mansour GK, et al. Therapeutic targeting of the hepcidin-ferroportin axis and erythropoietic modulators: a narrative review. Front Med (Lausanne). 2025;12:1726337. Published 2025 Dec 9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KY1070 関連分類
HY-P991881 関連分類
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