L-902688
Based on 3 publication(s) in Google Scholar
L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.0%
- CAS 番号: 634193-54-7
- 分子式: C21H27F2N5O2
- 分子量:419.47
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 L-902688
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生物活性
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EP4 0.38 nM (Ki) |
EP4 0.6 nM (EC50) |
L-902688 (1 µM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells (HUVECs)
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Concentration:1 µM
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Incubation Time:24 hours
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Result:Attenuated TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats injected with crotaline to induce pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy[1]
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Dosage:0.25 µg/kg/day, 0.4 µg/kg/day or 1 µg/kg/day
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Administration:Intraperitoneal injection; daily; for 3 weeks
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Result:Reduced right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.
化学情報
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CAS 番号 634193-54-7
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性状 Liquid
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分子量 419.47
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分子式 C21H27F2N5O2
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Color Colorless to light yellow
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SMILES
O[C@@]([H])(C(F)(C1=CC=CC=C1)F)/C=C/[C@@H](CCC2=O)N2CCCCCCC3=NN=NN3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Neurosci
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. [Abstract]2024 Aug;27(8):1534-1544. PMID: 38802591 -
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純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L-902688 関連分類
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