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United States

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製品番号: HY-163620

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LHQ490

LHQ490 is a selective FGFR2 inhibitor, with an IC₅₀ of 5.2 nM. LHQ490 efficiently inhibits the proliferation of BaF3-FGFR2 cells with an IC₅₀ value of 1.4 nM. LHQ490 inhibits FGFR2-driven cancer cell proliferation and induces apoptosis of FGFR2-driven cancer cells.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₀H₃₃FN₆O₂
分子量:528.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

LHQ490 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

FGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A204	IC₅₀	683 nM Compound: 9d; LHQ490	Antiproliferation activity against human A204 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay Antiproliferation activity against human A204 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
BaF3	IC₅₀	>1000 nM Compound: 9d; LHQ490	Antiproliferation activity against mouse BaF3 cells incubated for 72 hrs by CCK8 assay Antiproliferation activity against mouse BaF3 cells incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
BaF3	IC₅₀	1.4 nM Compound: 9d; LHQ490	Antiproliferation activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK8 assay Antiproliferation activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
BaF3	IC₅₀	98.7 nM Compound: 9d; LHQ490	Antiproliferation activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK8 assay Antiproliferation activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
MDA-MB-453	IC₅₀	>10000 nM Compound: 9d; LHQ490	Antiproliferation activity against human MDA-MB-453 cells harboring FGFR4 Y367C mutant incubated for 72 hrs by CCK8 assay Antiproliferation activity against human MDA-MB-453 cells harboring FGFR4 Y367C mutant incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
RT-112	IC₅₀	1790 nM Compound: 9d; LHQ490	Antiproliferation activity against human RT-112 cells harboring FGFR3-TACC3 incubated for 72 hrs by CCK8 assay Antiproliferation activity against human RT-112 cells harboring FGFR3-TACC3 incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
SNU-16	IC₅₀	12.9 nM Compound: 9d; LHQ490	Antiproliferation activity against human SNU-16 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay Antiproliferation activity against human SNU-16 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay	[PMID: 38718625]

化学情報

分子量 528.62
分子式 C₃₀H₃₃FN₆O₂
SMILES

C=CC(NC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3N2C)N)C4=CC=C(C(F)=C4)C5(COC5)N(C(C)C)CC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li H, et al. Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor. Eur J Med Chem. 2024 Jun 5;272:116473.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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