M4K2149
M4K2149 is a selective ALK2 inhibitor with an IC50 value of 17 nM. M4K2149 is applicable to research related to diffuse intrinsic pontine glioma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2421140-72-7
- 分子式: C24H26N4O2
- 分子量:402.50
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
ALK2 17 nM (IC50) |
M4K2149 potently inhibits WT ALK2 with an IC50 of 17 nM, shows comparable potency against DIPG-linked ALK2 mutants (ALK2G328V, ALK2R206H, ALK2R258G), and exhibits 34-fold selectivity for ALK2 over ALK5 in a radioactive in vitro biochemical kinase assay[1].
M4K2149 inhibits ALK2 binding in HEK293 cells with an IC50 of 55 nM in a NanoBRET assay and exhibits 13-fold cell-based selectivity for ALK2 over ALK5[1].
M4K2149 has reduced off-target activity against the hERG potassium channel in HEK293 cells, with an IC50 of >50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2421140-72-7
-
分子量 402.50
-
分子式 C24H26N4O2
-
SMILES
O=C(N)C1=CC=C(C=C1OC)C2=CN=CC(C3=CC=C(C=C3)N4CCNCC4)=C2C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
M4K2149 関連分類
HY-184317 関連分類
Powered by Bioz