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製品番号: HY-187523

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Methylolanthanin

Name: Methylolanthanin
Brand: MedChemExpress
SKU: HY-187523
Availability: PreOrder

(別名: para-MLL)

Methylolanthanin (para-MLL) is a natural small-molecule metallophore identified in the culture supernatant of Methylobacterium extorquens AM1. Methylolanthanin binds lanthanide metal ions such as La³⁺, Nd³⁺ and Lu³⁺. It is applicable to studies related to lanthanide metabolism, bacterial metallophores, metal homeostasis and methylotrophic metabolism.

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CAS 番号: 3120945-90-3
分子式: C₄₀H₅₈N₆O₁₁
分子量:798.92

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methylolanthanin 構造式

CAS 番号: 3120945-90-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体外実験

Methylolanthanin (para-MLL) (10 μM; 15 min) forms insoluble complexes with La³⁺, Nd³⁺, Eu³⁺, and Lu³⁺ at pH 6.0, causing the complexes to precipitate from the solution^[1].
Methylolanthanin (18.75 μM) exhibits low iron (III)-binding affinity and only weak ability to compete with the CAS/HDTMA complex for Fe³⁺ at pH 6.0^[1].
Methylolanthanin forms the [MLL-H+Ln³⁺]²⁺ complex with La³⁺, Nd³⁺ and Lu³⁺^[2].
Methylolanthanin (50 nM) significantly increases the growth yield of M. extorquens AM1 ΔmxaF and ΔmxaFΔmll mutants under conditions of 2 μM or 50 nM NdCl₃^[2].
Methylolanthanin binds Eu³⁺ within the micromolar and nanomolar concentration ranges and forms detectable Eu³⁺-MLL particles, with a log K_SP of -12.07 for the precipitated complex^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3120945-90-3
分子量 798.92
分子式 C₄₀H₅₈N₆O₁₁
SMILES

O=C(C(CC(NCCCCN(CCCCNC(C1=CC=C(C=C1)O)=O)C(C)=O)=O)(CC(NCCCCN(CCCCNC(C2=CC=C(C=C2)O)=O)C(C)=O)=O)O)O
別名

para-MLL
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Mertens MW, et al. Synthesis of two methylolanthanin derivatives and the investigation of their lanthanide and iron binding capabilities. Dalton transactions (Cambridge, England : 2003). 2026 Jul 14. [Content Brief]

[2]. Zytnick AM, et al. Identification and characterization of a small-molecule metallophore involved in lanthanide metabolism. Proc Natl Acad Sci U S A. 2024;121(32):e2322096121.

[3]. Gutenthaler-Tietze SM, et al. Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron. ChemBioChem. 2026;27(1):e202500312.

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How should lyophilized recombinant proteins be reconstituted and stored?

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