Mitomycin A
Based on 1 Customer Validation
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.3%
- CAS 番号: 4055-39-4
- 分子式: C16H19N3O6
- 分子量:349.34
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.006 μg/mL
Compound: 16
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in vitro anticancer activity against cultured A549 human tumor(lung) cell line
in vitro anticancer activity against cultured A549 human tumor(lung) cell line
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[PMID: 11585450] |
| CCRF S-180 | ED50 |
1.1 μg/mL
Compound: 28
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Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days
Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days
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[PMID: 19540628] |
| CCRF S-180 | ED50 |
1.3 mg/kg
Compound: mitomycin A
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Effective dose that gave 50 percent inhibition of sarcoma 180 tumor growth in ddY mice
Effective dose that gave 50 percent inhibition of sarcoma 180 tumor growth in ddY mice
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[PMID: 8021919] |
| HCT-8 | IC50 |
0.006 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured HCT-8 human tumor cell line
in vitro inhibition of tumor cell growth in cultured HCT-8 human tumor cell line
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[PMID: 11585450] |
| HeLa | IC50 |
0.0024 μM
Compound: mitomycin A
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In vitro anticellular activity tested against HeLa S3 cells
In vitro anticellular activity tested against HeLa S3 cells
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[PMID: 8021918] |
| HeLa | IC50 |
0.0024 μM
Compound: mitomycin A
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In vitro anticellular activity against HeLa S3 cells
In vitro anticellular activity against HeLa S3 cells
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[PMID: 8021919] |
| HepG2 | IC50 |
0.008 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured HepG2 human tumor cell line
in vitro inhibition of tumor cell growth in cultured HepG2 human tumor cell line
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[PMID: 11585450] |
| KB | IC50 |
0.008 μg/mL
Compound: 16
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in vitro anticancer activity against cultured KB(epidermoid) human tumor cell line
in vitro anticancer activity against cultured KB(epidermoid) human tumor cell line
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[PMID: 11585450] |
| L1210 | IC50 |
0.0023 μM
Compound: 6
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Inhibitory concentration on multidrug-resistant L1210 leukemia cells.
Inhibitory concentration on multidrug-resistant L1210 leukemia cells.
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[PMID: 1906107] |
| L1210 | IC50 |
0.0003 μM
Compound: 6
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Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
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[PMID: 1906107] |
| L1210 | IC50 |
0.3 nM
Compound: 6
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Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
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[PMID: 1906107] |
| MCF7 | IC50 |
0.045 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured MCF-7 human tumor cell line
in vitro inhibition of tumor cell growth in cultured MCF-7 human tumor cell line
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[PMID: 11585450] |
| MCF7 | IC50 |
0.63 nM
Compound: 20
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Antitumor potency on human breast MCF-7 cell lines.
Antitumor potency on human breast MCF-7 cell lines.
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[PMID: 1906109] |
| P388 | IC50 |
0.24 nM
Compound: 20
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Antitumor potency on P388 leukemia cells in culture
Antitumor potency on P388 leukemia cells in culture
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[PMID: 1906109] |
| PC-3 | IC50 |
0.02 μg/mL
Compound: 16
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in vitro inhibition of tumor cell growth in cultured PC-3 human tumor cell line
in vitro inhibition of tumor cell growth in cultured PC-3 human tumor cell line
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[PMID: 11585450] |
| U-87MG ATCC | IC50 |
0.009 μg/mL
Compound: 16
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in vitro anticancer activity against cultured U87MG (glioblastoma) human tumor cell line
in vitro anticancer activity against cultured U87MG (glioblastoma) human tumor cell line
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[PMID: 11585450] |
| WiDr | IC50 |
0.052 nM
Compound: 20
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Antitumor potency on human colon WIDR cell lines.
Antitumor potency on human colon WIDR cell lines.
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[PMID: 1906109] |
Mitomycin A (0.05-5 μg/mL; 24 h) inhibits the spontaneous migration of WEHI-3 mouse monocytes in a concentration-dependent manner[1].
Mitomycin A (0.25 μg/mL; 65 h) significantly inhibits the production of migration inhibitory factor (MIF) by pokeweed mitogen-activated human lymphocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WEHI-3 murine myelomonocytic leukemia cells
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Concentration:0.05 μg/mL; 0.1 μg/mL; 0.5 μg/mL; 5 μg/mL
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Incubation Time:24 h
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Result:Exhibited a migration index (MI) of 1.01 ± 0.05 at 0.05 μg/mL.
Showed a migration index (MI) of 1.03 ± 0.03 at 0.1 μg/mL.
Reduced the mean migration index (MI) to 0.65 ± 0.01 at 0.5 μg/mL, with a statistically significant decrease.
Lowered the mean migration index (MI) to 0.52 ± 0.02 at 5 μg/mL, with a statistically significant decrease.
Caused no statistically significant decreases in migration at 0.05 and 0.1 μg/mL.
化学情報
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CAS 番号 4055-39-4
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性状 Solid
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分子量 349.34
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分子式 C16H19N3O6
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Color Purple to purplish red
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SMILES
O=C1C(C)=C(OC)C(C2=C1N3[C@@]([C@](N4)([H])[C@]4([H])C3)(OC)[C@@H]2COC(N)=O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Mitomycin A 関連分類
HY-130332 関連分類
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