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製品番号: HY-148953

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MTR-106

Name: MTR-106
Brand: MedChemExpress
SKU: HY-148953
Price: 130.00 USD
Availability: InStock
Rating: 5 (1 reviews)

カスタマーレビュー

Based on 1 Customer Validation

MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 98.21%
CAS 番号: 1639357-93-9
分子式: C₂₈H₂₇N₇O₂S
分子量:525.62

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MTR-106 構造式

CAS 番号: 1639357-93-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

RNA Polymerase

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

MTR-106 (0-100 μM; 7 d) has antitumor activity in both HR-deficient cells and PARPi-resistant cells^[1].
MTR-106 (0-100 μM; 7 d) induces apoptosis, cell cycle arrest and DNA damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HR-deficient and PARPi-resistant cancer cells
Concentration:

0-100 μM
Incubation Time:

7 days
Result:

Inhibited the viability of HR-deficient cells and PARPi-resistant cells in a dose-dependent nanner.

Cell Cycle Analysis^[1]

Cell Line:

Capan-1 cells
Concentration:

0.1, 0.3, and 1 μM
Incubation Time:

24 hours
Result:

Increased in cells in G2/M, accompanied by a reduction in cell numbers in G1.

Western Blot Analysis^[1]

Cell Line:

Capan-1 cells
Concentration:

1, 5, and 10 μM
Incubation Time:

24 hours
Result:

Increased the cleaved caspases 3, 7, and 9 and cleaved PARP in a dose-dependent manner.

体内実験

MTR-106 (10-30 mg/kg; p.o.; twice a week, for 29 days) suppresses the tumor growth of BRCA-deficient and PARPi-resistant xenografts in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BRCA-deficient and PARPi-resistant xenografts in nude mice^[1]
Dosage:

10, 20, and 30 mg/kg
Administration:

oral administration; twice a week, for 29 days
Result:

Inhibited tumor growth in a dose-dependent manner.

Related Protocols :

化学情報

CAS 番号 1639357-93-9
性状 Solid
分子量 525.62
分子式 C₂₈H₂₇N₇O₂S
Color White to off-white
SMILES

CC1=CN=C(C=N1)CNC(C2=C3N(C4=CC=CC=C4S3)C5=NC(N6C[C@]7([H])[C@](CN(C7)C)([H])C6)=CC=C5C2=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 2 mg/mL (3.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9025 mL

9.5126 mL

19.0252 mL

5 mM

---

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li MZ, et, al. Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers. Invest New Drugs. 2021 Oct;39(5):1213-1221. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9025 mL	9.5126 mL	19.0252 mL	47.5629 mL

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MOQ

Minimum order quantity

100 mg

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