NRX-2663
Based on 1 publication(s) in Google Scholar
NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 μM and a Kd of 54.8 nM.
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- 純度: 98.96%
- CAS 番号: 2763260-34-8
- 分子式: C20H13F3N2O5
- 分子量:418.32
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 NRX-2663
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生物活性
製品説明
IC50 & Target
EC50: 22.9 µM (β-catenin:β-TrCP Interaction)[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)[1]
体外実験
NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 μM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2763260-34-8
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性状 Solid
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分子量 418.32
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分子式 C20H13F3N2O5
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Color White to light yellow
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SMILES
OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
2025 Oct:146:157099. PMID: 40774011
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (239.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3905 mL | 11.9526 mL | 23.9051 mL | 59.7629 mL |
| 5 mM | 0.4781 mL | 2.3905 mL | 4.7810 mL | 11.9526 mL | |
| 10 mM | 0.2391 mL | 1.1953 mL | 2.3905 mL | 5.9763 mL | |
| 15 mM | 0.1594 mL | 0.7968 mL | 1.5937 mL | 3.9842 mL | |
| 20 mM | 0.1195 mL | 0.5976 mL | 1.1953 mL | 2.9881 mL | |
| 25 mM | 0.0956 mL | 0.4781 mL | 0.9562 mL | 2.3905 mL | |
| 30 mM | 0.0797 mL | 0.3984 mL | 0.7968 mL | 1.9921 mL | |
| 40 mM | 0.0598 mL | 0.2988 mL | 0.5976 mL | 1.4941 mL | |
| 50 mM | 0.0478 mL | 0.2391 mL | 0.4781 mL | 1.1953 mL | |
| 60 mM | 0.0398 mL | 0.1992 mL | 0.3984 mL | 0.9960 mL | |
| 80 mM | 0.0299 mL | 0.1494 mL | 0.2988 mL | 0.7470 mL | |
| 100 mM | 0.0239 mL | 0.1195 mL | 0.2391 mL | 0.5976 mL |
NRX-2663 関連分類
HY-141448 関連分類
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