Oxindolylalanine
Based on 1 Customer Validation
Oxindolylalanine, a tryptophan analogue, is an inhibitor of tryptophan indole-lyase (Ki: 5 μM) and tryptophan synthase. Tryptophan indole-lyase is a bacterial enzyme which catalyzes the reversible formation of indole and ammonium pyruvate from L-tryptophan.
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- 純度: 98.0%
- CAS 番号: 32999-55-6
- 分子式: C11H12N2O3
- 分子量:220.22
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
生物活性
化学情報
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CAS 番号 32999-55-6
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性状 Solid
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分子量 220.22
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分子式 C11H12N2O3
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Color White to off-white
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SMILES
NC(C(O)=O)CC1C(NC2=C1C=CC=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 2 mg/mL (9.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Phillips RS, Buisman AA, Choi S, Hussaini A, Wood ZA. The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism. Acta Crystallogr D Struct Biol. 2018;74(Pt 8):748-759. [Content Brief]
[2]. Phillips RS, Harris AP. Structural Basis of the Stereochemistry of Inhibition of Tryptophan Synthase by Tryptophan and Derivatives. Biochemistry. 2021;60(3):231-244. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5409 mL | 22.7046 mL | 45.4091 mL | 113.5228 mL |
| 5 mM | 0.9082 mL | 4.5409 mL | 9.0818 mL | 22.7046 mL |