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製品番号: HY-183625

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PCA-IN-1

PCA-IN-1 is a polyisoprenylated cysteinyl amide (PCA) inhibitor that acts on multiple KRAS mutant subtypes. PCA-IN-1 dissociates KRAS4B from its transport chaperones, prevents its localization to the plasma membrane, and blocks downstream oncogenic signaling pathways. PCA-IN-1 inhibits colony formation of KRAS-mutant lung cancer cells, induces sustained long-term growth inhibition, and suppresses cell migration. PCA-IN-1 is applicable to the research of KRAS-mutant lung cancer.

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分子式: C₃₃H₅₈N₄O₂S
分子量:574.90

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PCA-IN-1 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

KRAS(G12C)

KRAS(G12A)

Ras アイソフォーム固有の製品をすべて表示 :

体外実験

PCA-IN-1 (PCAIs) (3 μM; 12 days) exerts broad anti-tumor activity by inhibiting colony formation in NCI-H23 KRAS^G12C and NCI-H23 KRAS^G12A cells^[1].
NSL-YHJ-2-27 potently inhibits the viability of NCI-H23 KRAS^G12C (IC₅₀ = 3.0 μM) and NCI-H23 KRAS^G12A (IC₅₀ = 3.2 μM) cells, with consistent efficacy across different mutants^[1].
PCA-IN-1 (26 d) exerts broad and sustained long-term growth inhibitory effects on NCI-H23 KRAS^G12C and NCI-H23 KRAS^G12A cells^[1].
PCA-IN-1 (3 d) significantly inhibits the migration of NCI-H23 KRAS^G12C and NCI-H23 KRAS^G12A cells, whereas Sotorasib (HY-114277) only inhibits the migration of cells carrying the KRAS^G12C mutant^[1].
PCA-IN-1 alters the transcriptome profile of KRAS-mutant NCI-H23 cells, with the changes enriched in signal transduction, cell adhesion and cancer-related pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

NCI-H23 KRAS^G12C, NCI-H23 KRAS^G12A
Concentration:

3 μM
Incubation Time:

12 days
Result:

Inhibited colony formation comparably to Sotorasib in NCI-H23 KRAS^G12C cells.
Showed significantly greater effectiveness in NCI-H23 KRAS^G12A cells than Sotorasib.

化学情報

分子量 574.90
分子式 C₃₃H₅₈N₄O₂S
SMILES

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CSCC(C(NC1CCCCCCC1)=O)NC(CN2CCN(CC2)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kwakye D, et al. Polyisoprenylated cysteinyl amide inhibitors suppress growth, induce cytoskeletal and transcriptomic remodeling in multiple KRAS-mutated lung cancer cells. Cancer Research. 2026 Apr 3;86(7_Supplement):1833-.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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PCA-IN-1

Ras アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

PCA-IN-1 関連分類

HY-183625 関連分類