Phytic acid hexasodium
Based on 1 publication(s) in Google Scholar
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 34367-89-0
- 分子式: C6H12Na6O24P6
- 分子量:791.93
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Phytic acid hexasodium
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Human Endogenous Metabolite |
化学情報
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CAS 番号 34367-89-0
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分子量 791.93
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分子式 C6H12Na6O24P6
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SMILES
O=P(O)(O[Na])O[C@H]1[C@H]([C@H]([C@@H]([C@H]([C@@H]1OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O
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別名
Inositol hexaphosphate hexasodium; SNF472
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
プロトコル
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
純度とドキュメンテーション
参考文献
[1]. Perelló J, et al. SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels. J Nephrol. 2018 Apr;31(2):287-296. [Content Brief]
[2]. Zabirnyk A,et al. SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification. Vascul Pharmacol. 2019 Nov-Dec;122-123:106583. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Phytic acid hexasodium 関連分類
HY-N0814B 関連分類
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