CD39
null CD39, the ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), is a two-transmembrane ectoenzyme that sequentially hydrolyzes extracellular ATP and ADP to AMP, which CD73 then converts to adenosine. Positioned at the head of the adenosinergic pathway, CD39 terminates purinergic danger signaling, inhibits platelet recruitment and feeds immunosuppressive adenosine generation. It is constitutively expressed on vascular endothelium and natural regulatory T cells, and inducibly on tumor-infiltrating lymphocytes and myeloid cells. Blocking CD39 is pursued to reinstate ATP-driven antitumor immunity, while soluble CD39 fusion proteins are explored for thrombosis and inflammation control.
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CD39 組換えタンパク質 (9)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
