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製品番号: HY-N20722

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Pulsatiloside C

Name: Pulsatiloside C
Brand: MedChemExpress
SKU: HY-N20722
Availability: PreOrder

(別名: Cussonoside A)

Pulsatiloside C (Cussonoside A) is an orally active triterpenoid saponin. Pulsatiloside C can be isolated from the roots of Pulsatilla campanella and the stem bark of Cussonia barteri. Pulsatiloside C exhibits sedative activity. Pulsatiloside C reduces locomotor activity in male Swiss albino mice. Pulsatiloside C shows no molluscicidal activity against Biomphalaria glabrata.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 57539-70-5
分子式: C₄₈H₇₈O₁₈
分子量:943.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pulsatiloside C 構造式

CAS 番号: 57539-70-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	50 μM Compound: 18	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay	[PMID: 31301930]
RAW264.7	IC₅₀	50 μM Compound: 21	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay	[PMID: 30808589]

体内実験

Pulsatiloside C (1 mg/kg; p.o.; single dose) produces time-dependent sedative activity in male Swiss albino mice by decreasing motility^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino (male, 25-30 g)^[3]
Dosage:

1 mg/kg
Administration:

p.o.; single dose
Result:

Decreased mouse motility with time-dependent effects that increased with time.

Related Protocols :

Protocol for Open Field Test (OF)

化学情報

CAS 番号 57539-70-5
分子量 943.13
分子式 C₄₈H₇₈O₁₈
SMILES

C(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@]45[C@](C=6[C@@](C)(CC4)[C@@]7(C)[C@](CC6)([C@]8(C)[C@@](CC7)([C@@](CO)(C)[C@@H](O)CC8)[H])[H])(CC(C)(C)CC5)[H]
別名

Cussonoside A
Structure Classification
- Terpenoids
- Pentacyclic Triterpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Li X C, et al. Triterpenoid saponins from Pulsatilla campanella[J]. Phytochemistry, 1990, 29(2): 595-599.

[2]. Dubois MA, et al. Cussonosides A and B, two triterpene-saponins from Cussonia barteri. Planta Med. 1986 Apr;(2):80-3. PMID: 3725939.

[3]. Igbe I, et al. Harnessing the medicinal properties of Cussonia barteri Seem.(Araliaceae) in drug development. A review[J]. Herba Polonica, 2018, 64(3).

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