Quinovic acid
Based on 1 Customer Validation
Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.0%
- CAS 番号: 465-74-7
- 分子式: C30H46O5
- 分子量:486.68
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Quinovic acid (5-115 μM, 24 h) shows low cytotoxicity and alleviates oligomeric Aβ (AβO)-induced cell death in SH-SY5Y cells[1].
Quinovic acid (85 μM, 24 h) downregulates AβO-induced expressions of p53 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in SH-SY5Y cells[1].
Quinovic acid (QA) (5-40 μM, 24-72 h) inhibits the proliferation and viability of A549, H1299, MCF-7 and MDA-MB-231 cells[2].
Quinovic acid (QA) (25-35 μM, 24 h) induces apoptosis in MDA-MB-231 and A549 cells[2].
Quinovic acid (25 μM, 4-24 h) upregulates the mRNA and protein levels of death receptor 5 (DR5) in A549, MCF-7, and MDA-MB-231 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 and A549 cells
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Concentration:25, 30 and 35 μM
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Incubation Time:24 h
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Result:Reduced procaspase 3 and 8 levels.
Increased cleaved PARP levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice treated with Aβ(1-42)[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneally injection, every other day for 3 weeks
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Result:Reduced Aβ oligomers, monomers, and BACE1 expression in cortex/hippocampus and decreased Aβ burden.
Downregulated p53 and HMGCR expressions and reduced total and free cholesterol levels.
Activated the Nrf2/HO-1 pathway, reduced ROS levels and restored GSH/GSSG ratio.
Downregulated GFAP, Iba-1, p-NF-κB, and IL-1β.
Downregulated Bax, cytochrome c, cleaved caspase-3; upregulates Bcl-2 and upregulated PSD-95 and synaptophysin.
Enhanced cognitive ability.
化学情報
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CAS 番号 465-74-7
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性状 Solid
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分子量 486.68
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分子式 C30H46O5
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Color White to off-white
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SMILES
OC([C@@]12C([C@@]3([H])[C@@](CC2)(CC[C@H]([C@@H]3C)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O)C)C)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Saeed K, et al. Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model. Oxid Med Cell Longev. 2020 Nov 20;2020:9523758. [Content Brief]
[2]. Khayam AU, et al. Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5. Mol Cell Biochem. 2020 Nov;474(1-2):159-169. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Quinovic acid 関連分類
HY-N1524 関連分類
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