RTI-263
RTI-263 is a biased Neuropeptide S receptor agonist. RTI-263 produces anxiolytic-like effects in rodents. RTI-263 reduces cocaine-seeking behavior in both male and female rats. RTI-263 does not modulate behaviors associated with natural rewards, including palatable food intake and fasting-induced food intake in rats. RTI-263 enhances memory in rodents without inducing increased arousal. RTI-263 can be used in studies related to substance use disorders and cocaine addiction.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C22H35N7O6
- 分子量:493.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
RTI-263 (1 nmole) induces anxiolytic-like behavior in male Sprague-Dawley rats, as evidenced by increased time spent in the light compartment of the light-dark box[1].
RTI-263 (10 nmole) antagonizes NPS-induced hyperlocomotion in male Sprague-Dawley rats[1].
RTI-263 (intracerebroventricular injection; single administration; 1-10 nmole) significantly reduces cue-induced cocaine-seeking behavior in male Sprague-Dawley rats[1].
RTI-263 (intracerebroventricular injection; single administration; 1-10 nmole) significantly reduces cue-induced cocaine-seeking behavior in female Sprague-Dawley rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 301-325 g)[1]
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Dosage:1 nmole
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Administration:i.c.v.; single injection; 10 min before testing
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Result:Displayed no increase in locomotor activity compared to vehicle control.
Showed no significant difference in fecal boli count relative to vehicle control.
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Animal Model:Sprague-Dawley (female, 190-200 g, 8 weeks old at arrival)[1]
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Dosage:1 nmole, 10 nmole
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Administration:i.c.v.; single injection; 5 min before reinstatement testing
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Result:Significantly reduced active lever responding during cue-induced reinstatement compared to vehicle control.
Showed no significant differences in inactive lever responding relative to control.
化学情報
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分子量 493.56
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分子式 C22H35N7O6
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SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)[C@H](CO)N
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配列
Ser-Phe-Lys-Asn-NH2
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シーケンスの短縮
SFKN-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Huang Y, et al. RTI-263, a biased neuropeptide S receptor agonist that retains an anxiolytic effect, attenuates cocaine-seeking behavior in rats. Neuropharmacology. 2023 Dec 15;241:109743. [Content Brief]
[2]. Caragea VM, et al. Neuropeptide S modulation of learning and memory: a systematic review. Behavioral and brain functions : BBF. 2026 May 03;22(1):17. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RTI-263 関連分類
HY-P12119 関連分類
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