(S)-Padsevonil
Based on 1 Customer Validation
(S)-Padsevonil is the S-enantiomer of Padsevonil (HY-109009).Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.40%
- CAS 番号: 1294001-37-8
- 分子式: C14H14ClF5N4O2S
- 分子量:432.80
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 1294001-37-8
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性状 Solid
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分子量 432.80
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分子式 C14H14ClF5N4O2S
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Color White to off-white
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SMILES
O=C1N(C[C@H](CC(F)(F)Cl)C1)CC(N(N=C(COC)S2)C2=N3)=C3C(F)(F)F
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別名
(S)-UCB-0942
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 200 mg/mL (462.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Niespodziany I, et al. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors. Epilepsia. 2020 May;61(5):914-923. [Content Brief]
[2]. Leclercq K, et al. Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3105 mL | 11.5527 mL | 23.1054 mL | 57.7634 mL |
| 5 mM | 0.4621 mL | 2.3105 mL | 4.6211 mL | 11.5527 mL | |
| 10 mM | 0.2311 mL | 1.1553 mL | 2.3105 mL | 5.7763 mL | |
| 15 mM | 0.1540 mL | 0.7702 mL | 1.5404 mL | 3.8509 mL | |
| 20 mM | 0.1155 mL | 0.5776 mL | 1.1553 mL | 2.8882 mL | |
| 25 mM | 0.0924 mL | 0.4621 mL | 0.9242 mL | 2.3105 mL | |
| 30 mM | 0.0770 mL | 0.3851 mL | 0.7702 mL | 1.9254 mL | |
| 40 mM | 0.0578 mL | 0.2888 mL | 0.5776 mL | 1.4441 mL | |
| 50 mM | 0.0462 mL | 0.2311 mL | 0.4621 mL | 1.1553 mL | |
| 60 mM | 0.0385 mL | 0.1925 mL | 0.3851 mL | 0.9627 mL | |
| 80 mM | 0.0289 mL | 0.1444 mL | 0.2888 mL | 0.7220 mL | |
| 100 mM | 0.0231 mL | 0.1155 mL | 0.2311 mL | 0.5776 mL |
(S)-Padsevonil 関連分類
HY-109009A 関連分類
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