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製品番号: HY-179243

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S3D5

S3D5 is a highly efficient and selective PROTAC degrader targeting STAT3 (KD = 4.35 μM). S3D5 induces degradation of STAT3 in HepG2 cells without significant effects on other STAT proteins. S3D5 exhibits good anti-hepatocellular carcinoma cell proliferation activity, which can be explained by activating the p53 pathway. S3D5 degradation of the STAT3 protein is mediated by the ubiquitin–proteasome system (UPS). S3D5 can be used for the study of hepatocellular carcinoma.
(Pink: STAT3 ligand (HY-163526); Blue: Cereblon ligand (HY-10984); Black: linker (HY-130447)).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3033746-21-0
分子式: C₄₁H₄₅F₅N₆O₁₃S
分子量:956.89

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

S3D5 構造式

CAS 番号: 3033746-21-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

S3D5 is a highly efficient and selective PROTAC degrader targeting STAT3 (KD = 4.35 μM). S3D5 induces degradation of STAT3 in HepG2 cells without significant effects on other STAT proteins. S3D5 exhibits good anti-hepatocellular carcinoma cell proliferation activity, which can be explained by activating the p53 pathway. S3D5 degradation of the STAT3 protein is mediated by the ubiquitin–proteasome system (UPS). S3D5 can be used for the study of hepatocellular carcinoma^[1]. (Pink: STAT3 ligand (HY-163526); Blue: Cereblon ligand (HY-10984); Black: linker (HY-130447)).

IC₅₀ & Target

STAT3

4.35 μM (Kd)

PROTACs アイソフォーム固有の製品をすべて表示 :

STAT アイソフォーム固有の製品をすべて表示 :

体外実験

S3D5 (4-20 μM, 96 h) shows optimal activity in HepG2 cells, with an IC₅₀ value of 8.53 μM^[1].
S3D5 (0.1-2 μM, 24-48 h) can induce STAT3 degradation in HepG2 cells (DC₅₀ = 110 nM), and have little effect at any concentration on STAT1, STAT2, STAT4, STAT5, and STAT6 proteins^[1].
S3D5 (2.5-20 μM, 96 h) inhibits the growth of HepG2 cells in a dose-dependent manner and inhibits the proliferation of 293T cells at 5 μM^[1].
S3D5 (1-20 μM, 14 days) leads to a significant reduction in both the number and size of HepG2 cell colonies compared to the control^[1].
S3D5 (5μM, 24-72 h) can inhibit the proliferation, migration and invasion of HepG2 cells^[1].
S3D5 (0.1-2 μM, 48 h) dose-dependently upregulates p53 and p21 protein levels, while downregulates STAT3 protein levels in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

0.1 μM, 0.2 μM, 0.5 μM
Incubation Time:

24 h
Result:

Induced STAT3 degradation in HepG2 cells.

Cell Proliferation Assay^[1]

Cell Line:

HepG2 cells
Concentration:

1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM
Incubation Time:

14 days
Result:

Led to a significant reduction in both the number and size of HepG2 cells.

Cell Invasion Assay^[1]

Cell Line:

HepG2 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Significantly inhibited the invasive ability of HepG2 cells.

Cell Migration Assay ^[1]

Cell Line:

HepG2 cells
Concentration:

5 μM
Incubation Time:

72 h
Result:

Significantly inhibited the migration ability of HepG2 cells.

化学情報

CAS 番号 3033746-21-0
分子量 956.89
分子式 C₄₁H₄₅F₅N₆O₁₃S
SMILES

CN(S(=O)(C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC(NC2=CC=C(C=C2)C(NCCOCCOCCOCCOCCOCCNC3=C4C(C(N(C5C(NC(CC5)=O)=O)C4=O)=O)=CC=C3)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang K, et al. Discovery of a potent and selective PROTAC degrader for STAT3. RSC Med Chem. 2025 Jul 31. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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S3D5

PROTACs アイソフォーム固有の製品をすべて表示

STAT アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

S3D5 関連分類

HY-179243 関連分類

Bioz

Keywords

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